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Analysing and reporting of observational data: a systematic review informing the EULAR points to consider when analysing and reporting comparative effectiveness research with observational data in rheumatology
OBJECTIVES: To evaluate the analysis and reporting of comparative effectiveness research with observational data in rheumatology, informing European Alliance of Associations for Rheumatology points to consider. METHODS: We performed a systematic literature review searching Ovid MEDLINE for original...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601074/ https://www.ncbi.nlm.nih.gov/pubmed/34789534 http://dx.doi.org/10.1136/rmdopen-2021-001818 |
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author | Lauper, Kim Kedra, Joanna de Wit, Maarten Fautrel, Bruno Frisell, Thomas Hyrich, Kimme L Iannone, Florenzo Machado, Pedro M Ørnbjerg, Lykke M Rotar, Ziga Santos, Maria Jose Stamm, Tanja A Stones, Simon R Strangfeld, Anja Landewé, Robert BM Finckh, Axel Bergstra, Sytske Anne Courvoisier, Delphine S |
author_facet | Lauper, Kim Kedra, Joanna de Wit, Maarten Fautrel, Bruno Frisell, Thomas Hyrich, Kimme L Iannone, Florenzo Machado, Pedro M Ørnbjerg, Lykke M Rotar, Ziga Santos, Maria Jose Stamm, Tanja A Stones, Simon R Strangfeld, Anja Landewé, Robert BM Finckh, Axel Bergstra, Sytske Anne Courvoisier, Delphine S |
author_sort | Lauper, Kim |
collection | PubMed |
description | OBJECTIVES: To evaluate the analysis and reporting of comparative effectiveness research with observational data in rheumatology, informing European Alliance of Associations for Rheumatology points to consider. METHODS: We performed a systematic literature review searching Ovid MEDLINE for original articles comparing drug effectiveness in longitudinal observational studies, published in key rheumatology journals between 2008 and 2019. The extracted information focused on reporting and types of analyses. We evaluated if year of publication impacted results. RESULTS: From 9969 abstracts reviewed, 211 articles fulfilled the inclusion criteria. Ten per cent of studies did not adjust for confounding factors. Some studies did not explain how they chose covariates for adjustment (9%), used bivariate screening (21%) and/or stepwise selection procedures (18%). Only 33% studies reported the number of patients lost to follow-up and 25% acknowledged attrition (drop-out or treatment cessation). To account for attrition, studies used non-responder imputation, followed by last observation carried forward (LOCF) and complete case (CC) analyses. Most studies did not report the number of missing data on covariates (83%), and when addressed, 49% used CC and 11% LOCF. Date of publication did not influence the results. CONCLUSION: Most studies did not acknowledge missing data and attrition, and a tenth did not adjust for any confounding factors. When attempting to account for them, several studies used methods which potentially increase bias (LOCF, CC analysis, bivariate screening…). This study shows that there is no improvement over the last decade, highlighting the need for recommendations for the assessment and reporting of comparative drug effectiveness in observational data in rheumatology. |
format | Online Article Text |
id | pubmed-8601074 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-86010742021-12-02 Analysing and reporting of observational data: a systematic review informing the EULAR points to consider when analysing and reporting comparative effectiveness research with observational data in rheumatology Lauper, Kim Kedra, Joanna de Wit, Maarten Fautrel, Bruno Frisell, Thomas Hyrich, Kimme L Iannone, Florenzo Machado, Pedro M Ørnbjerg, Lykke M Rotar, Ziga Santos, Maria Jose Stamm, Tanja A Stones, Simon R Strangfeld, Anja Landewé, Robert BM Finckh, Axel Bergstra, Sytske Anne Courvoisier, Delphine S RMD Open Epidemiology OBJECTIVES: To evaluate the analysis and reporting of comparative effectiveness research with observational data in rheumatology, informing European Alliance of Associations for Rheumatology points to consider. METHODS: We performed a systematic literature review searching Ovid MEDLINE for original articles comparing drug effectiveness in longitudinal observational studies, published in key rheumatology journals between 2008 and 2019. The extracted information focused on reporting and types of analyses. We evaluated if year of publication impacted results. RESULTS: From 9969 abstracts reviewed, 211 articles fulfilled the inclusion criteria. Ten per cent of studies did not adjust for confounding factors. Some studies did not explain how they chose covariates for adjustment (9%), used bivariate screening (21%) and/or stepwise selection procedures (18%). Only 33% studies reported the number of patients lost to follow-up and 25% acknowledged attrition (drop-out or treatment cessation). To account for attrition, studies used non-responder imputation, followed by last observation carried forward (LOCF) and complete case (CC) analyses. Most studies did not report the number of missing data on covariates (83%), and when addressed, 49% used CC and 11% LOCF. Date of publication did not influence the results. CONCLUSION: Most studies did not acknowledge missing data and attrition, and a tenth did not adjust for any confounding factors. When attempting to account for them, several studies used methods which potentially increase bias (LOCF, CC analysis, bivariate screening…). This study shows that there is no improvement over the last decade, highlighting the need for recommendations for the assessment and reporting of comparative drug effectiveness in observational data in rheumatology. BMJ Publishing Group 2021-11-17 /pmc/articles/PMC8601074/ /pubmed/34789534 http://dx.doi.org/10.1136/rmdopen-2021-001818 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Epidemiology Lauper, Kim Kedra, Joanna de Wit, Maarten Fautrel, Bruno Frisell, Thomas Hyrich, Kimme L Iannone, Florenzo Machado, Pedro M Ørnbjerg, Lykke M Rotar, Ziga Santos, Maria Jose Stamm, Tanja A Stones, Simon R Strangfeld, Anja Landewé, Robert BM Finckh, Axel Bergstra, Sytske Anne Courvoisier, Delphine S Analysing and reporting of observational data: a systematic review informing the EULAR points to consider when analysing and reporting comparative effectiveness research with observational data in rheumatology |
title | Analysing and reporting of observational data: a systematic review informing the EULAR points to consider when analysing and reporting comparative effectiveness research with observational data in rheumatology |
title_full | Analysing and reporting of observational data: a systematic review informing the EULAR points to consider when analysing and reporting comparative effectiveness research with observational data in rheumatology |
title_fullStr | Analysing and reporting of observational data: a systematic review informing the EULAR points to consider when analysing and reporting comparative effectiveness research with observational data in rheumatology |
title_full_unstemmed | Analysing and reporting of observational data: a systematic review informing the EULAR points to consider when analysing and reporting comparative effectiveness research with observational data in rheumatology |
title_short | Analysing and reporting of observational data: a systematic review informing the EULAR points to consider when analysing and reporting comparative effectiveness research with observational data in rheumatology |
title_sort | analysing and reporting of observational data: a systematic review informing the eular points to consider when analysing and reporting comparative effectiveness research with observational data in rheumatology |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601074/ https://www.ncbi.nlm.nih.gov/pubmed/34789534 http://dx.doi.org/10.1136/rmdopen-2021-001818 |
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