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Integrating continuous hypermutation with high‐throughput screening for optimization of cis,cis‐muconic acid production in yeast
Directed evolution is a powerful method to optimize proteins and metabolic reactions towards user‐defined goals. It usually involves subjecting genes or pathways to iterative rounds of mutagenesis, selection and amplification. While powerful, systematic searches through large sequence‐spaces is a la...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601171/ https://www.ncbi.nlm.nih.gov/pubmed/33645919 http://dx.doi.org/10.1111/1751-7915.13774 |