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Acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study
BACKGROUND & AIM: Screening for genital infection (GI) such as bacterial vaginosis (BV) and yeast infection, for sexually transmitted infection (STI), and for asymptomatic carriage of group B streptococcus (GBS) in pregnant women are common reason for medical appointments. The diagnosis and cont...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601421/ https://www.ncbi.nlm.nih.gov/pubmed/34793548 http://dx.doi.org/10.1371/journal.pone.0260021 |
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author | Camus, Claire Penaranda, Guillaume Khiri, Hacène Camiade, Sabine Molet, Lucie Lebsir, Melissa Plauzolles, Anne Chiche, Laurent Blanc, Bernard Quarello, Edwin Halfon, Philippe |
author_facet | Camus, Claire Penaranda, Guillaume Khiri, Hacène Camiade, Sabine Molet, Lucie Lebsir, Melissa Plauzolles, Anne Chiche, Laurent Blanc, Bernard Quarello, Edwin Halfon, Philippe |
author_sort | Camus, Claire |
collection | PubMed |
description | BACKGROUND & AIM: Screening for genital infection (GI) such as bacterial vaginosis (BV) and yeast infection, for sexually transmitted infection (STI), and for asymptomatic carriage of group B streptococcus (GBS) in pregnant women are common reason for medical appointments. The diagnosis and control of GIs, STIs, and GBS are major issues, for fertility and overall well-being of affected women. Conventional testing is performed using vaginal/cervical classical sampling (VCS); this procedure requires pelvic examination performed by health care professionals which raises concerns among women. Vaginal-self-sampling (VSS), as an alternative to VCS, might capture more women. The aim was first to show non-inferiority of VSS compared with VCS to screen for GIs, STIs, and GBS; second to determine the feasibility of VSS. METHODS: VSS and VCS from 1027 women were collected by health care professionals and simultaneously carried out on each patient. GIs, STIs, and GBS were systematically screened in both paired VSS and VCS samples. Non-inferiority of VSS compared with VCS was assessed using z statistic for binomial proportions. RESULTS: Prevalence of GIs were 39.7% using VSS and 38.1% using VCS (p = 0.0016). Prevalence of STIs was 8.5% (VSS) vs 8.1% (VCS) (p = 0.0087). Prevalence of GBS was 13.4% (VSS) and 11.5% (VCS) (p = 0.0001). Most participants (84%) recommended the use of VSS. CONCLUSIONS: This study shows that VSS was not inferior to VCS for the detection of GIs, STIs, and GBS. This study provides evidence that VSS can be used as a universal specimen for detection of lower genital tract infections in women. STUDY IDENTIFICATION NUMBER: ID-RCB 2014-A01250-4. |
format | Online Article Text |
id | pubmed-8601421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-86014212021-11-19 Acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study Camus, Claire Penaranda, Guillaume Khiri, Hacène Camiade, Sabine Molet, Lucie Lebsir, Melissa Plauzolles, Anne Chiche, Laurent Blanc, Bernard Quarello, Edwin Halfon, Philippe PLoS One Research Article BACKGROUND & AIM: Screening for genital infection (GI) such as bacterial vaginosis (BV) and yeast infection, for sexually transmitted infection (STI), and for asymptomatic carriage of group B streptococcus (GBS) in pregnant women are common reason for medical appointments. The diagnosis and control of GIs, STIs, and GBS are major issues, for fertility and overall well-being of affected women. Conventional testing is performed using vaginal/cervical classical sampling (VCS); this procedure requires pelvic examination performed by health care professionals which raises concerns among women. Vaginal-self-sampling (VSS), as an alternative to VCS, might capture more women. The aim was first to show non-inferiority of VSS compared with VCS to screen for GIs, STIs, and GBS; second to determine the feasibility of VSS. METHODS: VSS and VCS from 1027 women were collected by health care professionals and simultaneously carried out on each patient. GIs, STIs, and GBS were systematically screened in both paired VSS and VCS samples. Non-inferiority of VSS compared with VCS was assessed using z statistic for binomial proportions. RESULTS: Prevalence of GIs were 39.7% using VSS and 38.1% using VCS (p = 0.0016). Prevalence of STIs was 8.5% (VSS) vs 8.1% (VCS) (p = 0.0087). Prevalence of GBS was 13.4% (VSS) and 11.5% (VCS) (p = 0.0001). Most participants (84%) recommended the use of VSS. CONCLUSIONS: This study shows that VSS was not inferior to VCS for the detection of GIs, STIs, and GBS. This study provides evidence that VSS can be used as a universal specimen for detection of lower genital tract infections in women. STUDY IDENTIFICATION NUMBER: ID-RCB 2014-A01250-4. Public Library of Science 2021-11-18 /pmc/articles/PMC8601421/ /pubmed/34793548 http://dx.doi.org/10.1371/journal.pone.0260021 Text en © 2021 Camus et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Camus, Claire Penaranda, Guillaume Khiri, Hacène Camiade, Sabine Molet, Lucie Lebsir, Melissa Plauzolles, Anne Chiche, Laurent Blanc, Bernard Quarello, Edwin Halfon, Philippe Acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study |
title | Acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study |
title_full | Acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study |
title_fullStr | Acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study |
title_full_unstemmed | Acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study |
title_short | Acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study |
title_sort | acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: a cross-sectional study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601421/ https://www.ncbi.nlm.nih.gov/pubmed/34793548 http://dx.doi.org/10.1371/journal.pone.0260021 |
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