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Heterologous expression and purification of recombinant human protoporphyrinogen oxidase IX: A comparative study

Human protoporphyrinogen oxidase IX (hPPO) is an oxygen-dependent enzyme catalyzing the penultimate step in the heme biosynthesis pathway. Mutations in the enzyme are linked to variegate porphyria, an autosomal dominant metabolic disease. Here we investigated eukaryotic cells as alternative systems...

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Detalles Bibliográficos
Autores principales:	Novakova, Zora, Khuntsaria, Daria, Gresova, Marketa, Mikesova, Jana, Havlinova, Barbora, Shukla, Shivam, Kolarova, Lucie, Vesela, Katerina, Martasek, Pavel, Barinka, Cyril
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601502/ https://www.ncbi.nlm.nih.gov/pubmed/34793488 http://dx.doi.org/10.1371/journal.pone.0259837

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