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The clinical course of hospitalized moderately ill COVID-19 patients is mirrored by routine hematologic tests and influenced by renal transplantation

Several studies of patients with COVID-19 have evaluated biological markers for predicting outcomes, most of them retrospectively and with a wide scope of clinical severity. We followed a prospective cohort of patients admitted in hospital wards with moderate COVID-19 disease, including those with a...

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Autores principales: Peçanha-Pietrobom, Paula M., Leite, Giuseppe Gianini Figueirêdo, Hunter, James, Ferreira, Paulo R. Abrão, Burattini, Marcelo N., Bellei, Nancy, Ota-Arakaki, Jaquelina Sonoe, Salomao, Reinaldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601535/
https://www.ncbi.nlm.nih.gov/pubmed/34793468
http://dx.doi.org/10.1371/journal.pone.0258987
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author Peçanha-Pietrobom, Paula M.
Leite, Giuseppe Gianini Figueirêdo
Hunter, James
Ferreira, Paulo R. Abrão
Burattini, Marcelo N.
Bellei, Nancy
Ota-Arakaki, Jaquelina Sonoe
Salomao, Reinaldo
author_facet Peçanha-Pietrobom, Paula M.
Leite, Giuseppe Gianini Figueirêdo
Hunter, James
Ferreira, Paulo R. Abrão
Burattini, Marcelo N.
Bellei, Nancy
Ota-Arakaki, Jaquelina Sonoe
Salomao, Reinaldo
author_sort Peçanha-Pietrobom, Paula M.
collection PubMed
description Several studies of patients with COVID-19 have evaluated biological markers for predicting outcomes, most of them retrospectively and with a wide scope of clinical severity. We followed a prospective cohort of patients admitted in hospital wards with moderate COVID-19 disease, including those with a history of kidney transplantation, and examined the ability of changes in routine hematologic laboratory parameters to predict and mirror the patients’ clinical course regarding the severity of their condition (classified as critical vs. non-critical) and in-hospital mortality or hospital discharge. Among the 68 patients, 20 (29%) were kidney transplanted patients (KT), and they had much higher mortality than non-kidney transplanted patients in this cohort (40% X 8.3%). Lymphocytes, neutrophils and neutrophils/lymphocytes ratio (NLR) at admission and platelets as well as the red blood cells parameters hemoglobin, hematocrit, and RDW by the time of hospital discharge or death clearly differentiated patients progressing to critical disease and those with clinical recovery. Patients with deteriorating clinical courses presented elevated and similar NLRs during the first week of hospitalization. However, they were dramatically different at hospital discharge, with a decrease in the survivors (NLR around 5.5) and sustained elevation in non-survivors (NLR around 21). Platelets also could distinguish survivors from non-survivors among the critical patients. In conclusion, routine hematologic tests are useful to monitor the clinical course of COVID-19 patients admitted with moderate disease. Unexpectedly, changes in hematologic tests, including lymphopenia, were not predictive of complicated outcomes among KT recipients.
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spelling pubmed-86015352021-11-19 The clinical course of hospitalized moderately ill COVID-19 patients is mirrored by routine hematologic tests and influenced by renal transplantation Peçanha-Pietrobom, Paula M. Leite, Giuseppe Gianini Figueirêdo Hunter, James Ferreira, Paulo R. Abrão Burattini, Marcelo N. Bellei, Nancy Ota-Arakaki, Jaquelina Sonoe Salomao, Reinaldo PLoS One Research Article Several studies of patients with COVID-19 have evaluated biological markers for predicting outcomes, most of them retrospectively and with a wide scope of clinical severity. We followed a prospective cohort of patients admitted in hospital wards with moderate COVID-19 disease, including those with a history of kidney transplantation, and examined the ability of changes in routine hematologic laboratory parameters to predict and mirror the patients’ clinical course regarding the severity of their condition (classified as critical vs. non-critical) and in-hospital mortality or hospital discharge. Among the 68 patients, 20 (29%) were kidney transplanted patients (KT), and they had much higher mortality than non-kidney transplanted patients in this cohort (40% X 8.3%). Lymphocytes, neutrophils and neutrophils/lymphocytes ratio (NLR) at admission and platelets as well as the red blood cells parameters hemoglobin, hematocrit, and RDW by the time of hospital discharge or death clearly differentiated patients progressing to critical disease and those with clinical recovery. Patients with deteriorating clinical courses presented elevated and similar NLRs during the first week of hospitalization. However, they were dramatically different at hospital discharge, with a decrease in the survivors (NLR around 5.5) and sustained elevation in non-survivors (NLR around 21). Platelets also could distinguish survivors from non-survivors among the critical patients. In conclusion, routine hematologic tests are useful to monitor the clinical course of COVID-19 patients admitted with moderate disease. Unexpectedly, changes in hematologic tests, including lymphopenia, were not predictive of complicated outcomes among KT recipients. Public Library of Science 2021-11-18 /pmc/articles/PMC8601535/ /pubmed/34793468 http://dx.doi.org/10.1371/journal.pone.0258987 Text en © 2021 Peçanha-Pietrobom et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Peçanha-Pietrobom, Paula M.
Leite, Giuseppe Gianini Figueirêdo
Hunter, James
Ferreira, Paulo R. Abrão
Burattini, Marcelo N.
Bellei, Nancy
Ota-Arakaki, Jaquelina Sonoe
Salomao, Reinaldo
The clinical course of hospitalized moderately ill COVID-19 patients is mirrored by routine hematologic tests and influenced by renal transplantation
title The clinical course of hospitalized moderately ill COVID-19 patients is mirrored by routine hematologic tests and influenced by renal transplantation
title_full The clinical course of hospitalized moderately ill COVID-19 patients is mirrored by routine hematologic tests and influenced by renal transplantation
title_fullStr The clinical course of hospitalized moderately ill COVID-19 patients is mirrored by routine hematologic tests and influenced by renal transplantation
title_full_unstemmed The clinical course of hospitalized moderately ill COVID-19 patients is mirrored by routine hematologic tests and influenced by renal transplantation
title_short The clinical course of hospitalized moderately ill COVID-19 patients is mirrored by routine hematologic tests and influenced by renal transplantation
title_sort clinical course of hospitalized moderately ill covid-19 patients is mirrored by routine hematologic tests and influenced by renal transplantation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601535/
https://www.ncbi.nlm.nih.gov/pubmed/34793468
http://dx.doi.org/10.1371/journal.pone.0258987
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