Cargando…

Adult medial habenula neurons require GDNF receptor GFRα1 for synaptic stability and function

The medial habenula (mHb) is an understudied small brain nucleus linking forebrain and midbrain structures controlling anxiety and fear behaviors. The mechanisms that maintain the structural and functional integrity of mHb neurons and their synapses remain unknown. Using spatiotemporally controlled...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fernández-Suárez, Diana, Krapacher, Favio A., Pietrajtis, Katarzyna, Andersson, Annika, Kisiswa, Lilian, Carrier-Ruiz, Alvaro, Diana, Marco A., Ibáñez, Carlos F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601618/ https://www.ncbi.nlm.nih.gov/pubmed/34748545 http://dx.doi.org/10.1371/journal.pbio.3001350

Ejemplares similares

MAG induces apoptosis in cerebellar granule neurons through p75(NTR) demarcating granule layer/white matter boundary
por: Fernández-Suárez, Diana, et al.
Publicado: (2019)

Correction: MAG induces apoptosis in cerebellar granule neurons through p75(NTR) demarcating granule layer/white matter boundary
por: Fernández-Suárez, Diana, et al.
Publicado: (2019)

Convergent dopamine and ALK4 signaling to PCBP1 controls FosB alternative splicing and cocaine behavioral sensitization
por: Krapacher, Favio A, et al.
Publicado: (2022)

Functional Principles of Posterior Septal Inputs to the Medial Habenula
por: Otsu, Yo, et al.
Publicado: (2018)

Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly
por: Houghton, F. M., et al.
Publicado: (2023)

RET-independent signaling by GDNF ligands and GFRα receptors
por: Ibáñez, Carlos F., et al.
Publicado: (2020)

ALK4 coordinates extracellular and intrinsic signals to regulate development of cortical somatostatin interneurons
por: Göngrich, Christina, et al.
Publicado: (2019)

The medial habenula: still neglected
por: Viswanath, Humsini, et al.
Publicado: (2014)

Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7
por: Marmol, Patricia, et al.
Publicado: (2020)

Synaptic and cellular profile of neurons in the lateral habenula
por: Meye, Frank J., et al.
Publicado: (2013)

Mild stress accumulation limits GABAergic synaptic plasticity in the lateral habenula
por: Lalive, Arnaud L., et al.
Publicado: (2022)

TGFβ induces GDNF responsiveness in neurons by recruitment of GFRα1 to the plasma membrane
por: Peterziel, H., et al.
Publicado: (2002)

Dorsal Medial Habenula Regulation of Mood-Related Behaviors and Primary Reinforcement by Tachykinin-Expressing Habenula Neurons
por: Hsu, Yun-Wei A., et al.
Publicado: (2016)

The medial habenula as a regulator of anxiety in adult zebrafish
por: Mathuru, Ajay S., et al.
Publicado: (2013)

Cell-autonomous role of GFRα1 in the development of olfactory bulb GABAergic interneurons
por: Zechel, Sabrina, et al.
Publicado: (2018)

Simultaneous Detection of Both GDNF and GFRα1 Expression Patterns in the Mouse Central Nervous System
por: Ortega-de San Luis, Clara, et al.
Publicado: (2016)

Compromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRα1 or RET Impairs Normal Cerebellar Motor Learning
por: Sergaki, Maria Christina, et al.
Publicado: (2017)

Fetal Medial Habenula Transplants: Innervation of the Rat Interpeduncular Nucleus
por: Lenn, Nicholas J., et al.
Publicado: (1989)

Daily variation in the electrophysiological activity of mouse medial habenula neurones
por: Sakhi, Kanwal, et al.
Publicado: (2014)

Data on in vivo phenotypes of GFRα1-positive spermatogonia stimulated by interstitial GDNF signals in mouse testes
por: Uchida, Aya, et al.
Publicado: (2016)

GDNF/GFRα1 Complex Abrogates Self-Renewing Activity of Cortical Neural Precursors Inducing Their Differentiation
por: Bonafina, Antonela, et al.
Publicado: (2018)

Induction of GDNF and GFRα-1 Following AAV1-Rheb(S16H) Administration in the Hippocampus in vivo
por: Yun, Dongyoung, et al.
Publicado: (2020)

Genetic dissection of medial habenula–interpeduncular nucleus pathway function in mice
por: Kobayashi, Yuki, et al.
Publicado: (2013)

The Role of the Medial Habenula Cholinergic System in Addiction and Emotion-Associated Behaviors
por: Lee, Hyun Woo, et al.
Publicado: (2019)

Stress undermines reward-guided cognitive performance through synaptic depression in the lateral habenula
por: Nuno-Perez, Alvaro, et al.
Publicado: (2021)

Mutation and deletion analysis of GFRα-1, encoding the co-receptor for the GDNF/RET complex, in human brain tumours
por: Gimm, O, et al.
Publicado: (1999)

Role of GDNF, GFRα1 and GFAP in a Bifidobacterium-Intervention Induced Mouse Model of Intestinal Neuronal Dysplasia
por: Liu, Wei, et al.
Publicado: (2022)

Synaptic potentiation onto habenula neurons in learned helplessness model of depression
por: Li, Bo, et al.
Publicado: (2011)

Age‐related changes in hippocampal‐dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor
por: Wong, Lik‐Wei, et al.
Publicado: (2021)

Optogenetic activation of septal GABAergic afferents entrains neuronal firing in the medial habenula
por: Choi, Kyuhyun, et al.
Publicado: (2016)

Medial habenula cholinergic signaling regulates cocaine‐associated relapse‐like behavior
por: López, Alberto J., et al.
Publicado: (2018)

PM317. Characterization of nicotinic neural activities in rat medial and lateral habenula
por: Lee, Hyunchan, et al.
Publicado: (2016)

Differential regulation of neuronal excitability by nicotine and substance P in subdivisions of the medial habenula
por: Lee, Changwoo, et al.
Publicado: (2018)

Nicotine Self-Administration Induces Plastic Changes to Nicotinic Receptors in Medial Habenula
por: Jin, Xiao-Tao, et al.
Publicado: (2020)

GDNF promotes tubulogenesis of GFRα1-expressing MDCK cells by Src-mediated phosphorylation of Met receptor tyrosine kinase
por: Popsueva, Anna, et al.
Publicado: (2003)

The Zebrafish Dorsolateral Habenula Is Required for Updating Learned Behaviors
por: Palumbo, Fabrizio, et al.
Publicado: (2020)

Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro
por: Saarenpää, Tuulia, et al.
Publicado: (2017)

APE1 Promotes Pancreatic Cancer Proliferation through GFRα1/Src/ERK Axis-Cascade Signaling in Response to GDNF
por: Choi, Yoo-Duk, et al.
Publicado: (2020)

T-Type Calcium Channels Contribute to Burst Firing in a Subpopulation of Medial Habenula Neurons
por: Vickstrom, Casey R., et al.
Publicado: (2020)

Disruption of VGLUT1 in Cholinergic Medial Habenula Projections Increases Nicotine Self-Administration
por: Souter, Elizabeth A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_t79pcbkdgos2gf9cspl9okj531