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Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate

Until recently, the study of major histocompability complex (MHC) mediated immunity has focused on the direct link between MHC diversity and susceptibility to parasite infection. However, MHC genes can also influence host health indirectly through the sculpting of the bacterial community that in tur...

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Autores principales: Montero, B. Karina, Wasimuddin, Schwensow, Nina, Gillingham, Mark A. F., Ratovonamana, Yedidya R., Rakotondranary, S. Jacques, Corman, Victor, Drosten, Christian, Ganzhorn, Jörg U., Sommer, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601626/
https://www.ncbi.nlm.nih.gov/pubmed/34748618
http://dx.doi.org/10.1371/journal.ppat.1009675
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author Montero, B. Karina
Wasimuddin,
Schwensow, Nina
Gillingham, Mark A. F.
Ratovonamana, Yedidya R.
Rakotondranary, S. Jacques
Corman, Victor
Drosten, Christian
Ganzhorn, Jörg U.
Sommer, Simone
author_facet Montero, B. Karina
Wasimuddin,
Schwensow, Nina
Gillingham, Mark A. F.
Ratovonamana, Yedidya R.
Rakotondranary, S. Jacques
Corman, Victor
Drosten, Christian
Ganzhorn, Jörg U.
Sommer, Simone
author_sort Montero, B. Karina
collection PubMed
description Until recently, the study of major histocompability complex (MHC) mediated immunity has focused on the direct link between MHC diversity and susceptibility to parasite infection. However, MHC genes can also influence host health indirectly through the sculpting of the bacterial community that in turn shape immune responses. We investigated the links between MHC class I and II gene diversity gut microbiome diversity and micro- (adenovirus, AdV) and macro- (helminth) parasite infection probabilities in a wild population of non-human primates, mouse lemurs of Madagascar. This setup encompasses a plethora of underlying interactions between parasites, microbes and adaptive immunity in natural populations. Both MHC classes explained shifts in microbiome composition and the effect was driven by a few select microbial taxa. Among them were three taxa (Odoribacter, Campylobacter and Prevotellaceae-UCG-001) which were in turn linked to AdV and helminth infection status, correlative evidence of the indirect effect of the MHC via the microbiome. Our study provides support for the coupled role of MHC diversity and microbial flora as contributing factors of parasite infection.
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spelling pubmed-86016262021-11-19 Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate Montero, B. Karina Wasimuddin, Schwensow, Nina Gillingham, Mark A. F. Ratovonamana, Yedidya R. Rakotondranary, S. Jacques Corman, Victor Drosten, Christian Ganzhorn, Jörg U. Sommer, Simone PLoS Pathog Research Article Until recently, the study of major histocompability complex (MHC) mediated immunity has focused on the direct link between MHC diversity and susceptibility to parasite infection. However, MHC genes can also influence host health indirectly through the sculpting of the bacterial community that in turn shape immune responses. We investigated the links between MHC class I and II gene diversity gut microbiome diversity and micro- (adenovirus, AdV) and macro- (helminth) parasite infection probabilities in a wild population of non-human primates, mouse lemurs of Madagascar. This setup encompasses a plethora of underlying interactions between parasites, microbes and adaptive immunity in natural populations. Both MHC classes explained shifts in microbiome composition and the effect was driven by a few select microbial taxa. Among them were three taxa (Odoribacter, Campylobacter and Prevotellaceae-UCG-001) which were in turn linked to AdV and helminth infection status, correlative evidence of the indirect effect of the MHC via the microbiome. Our study provides support for the coupled role of MHC diversity and microbial flora as contributing factors of parasite infection. Public Library of Science 2021-11-08 /pmc/articles/PMC8601626/ /pubmed/34748618 http://dx.doi.org/10.1371/journal.ppat.1009675 Text en © 2021 Montero et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Montero, B. Karina
Wasimuddin,
Schwensow, Nina
Gillingham, Mark A. F.
Ratovonamana, Yedidya R.
Rakotondranary, S. Jacques
Corman, Victor
Drosten, Christian
Ganzhorn, Jörg U.
Sommer, Simone
Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate
title Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate
title_full Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate
title_fullStr Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate
title_full_unstemmed Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate
title_short Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate
title_sort evidence of mhc class i and ii influencing viral and helminth infection via the microbiome in a non-human primate
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601626/
https://www.ncbi.nlm.nih.gov/pubmed/34748618
http://dx.doi.org/10.1371/journal.ppat.1009675
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