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Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate
Until recently, the study of major histocompability complex (MHC) mediated immunity has focused on the direct link between MHC diversity and susceptibility to parasite infection. However, MHC genes can also influence host health indirectly through the sculpting of the bacterial community that in tur...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601626/ https://www.ncbi.nlm.nih.gov/pubmed/34748618 http://dx.doi.org/10.1371/journal.ppat.1009675 |
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author | Montero, B. Karina Wasimuddin, Schwensow, Nina Gillingham, Mark A. F. Ratovonamana, Yedidya R. Rakotondranary, S. Jacques Corman, Victor Drosten, Christian Ganzhorn, Jörg U. Sommer, Simone |
author_facet | Montero, B. Karina Wasimuddin, Schwensow, Nina Gillingham, Mark A. F. Ratovonamana, Yedidya R. Rakotondranary, S. Jacques Corman, Victor Drosten, Christian Ganzhorn, Jörg U. Sommer, Simone |
author_sort | Montero, B. Karina |
collection | PubMed |
description | Until recently, the study of major histocompability complex (MHC) mediated immunity has focused on the direct link between MHC diversity and susceptibility to parasite infection. However, MHC genes can also influence host health indirectly through the sculpting of the bacterial community that in turn shape immune responses. We investigated the links between MHC class I and II gene diversity gut microbiome diversity and micro- (adenovirus, AdV) and macro- (helminth) parasite infection probabilities in a wild population of non-human primates, mouse lemurs of Madagascar. This setup encompasses a plethora of underlying interactions between parasites, microbes and adaptive immunity in natural populations. Both MHC classes explained shifts in microbiome composition and the effect was driven by a few select microbial taxa. Among them were three taxa (Odoribacter, Campylobacter and Prevotellaceae-UCG-001) which were in turn linked to AdV and helminth infection status, correlative evidence of the indirect effect of the MHC via the microbiome. Our study provides support for the coupled role of MHC diversity and microbial flora as contributing factors of parasite infection. |
format | Online Article Text |
id | pubmed-8601626 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-86016262021-11-19 Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate Montero, B. Karina Wasimuddin, Schwensow, Nina Gillingham, Mark A. F. Ratovonamana, Yedidya R. Rakotondranary, S. Jacques Corman, Victor Drosten, Christian Ganzhorn, Jörg U. Sommer, Simone PLoS Pathog Research Article Until recently, the study of major histocompability complex (MHC) mediated immunity has focused on the direct link between MHC diversity and susceptibility to parasite infection. However, MHC genes can also influence host health indirectly through the sculpting of the bacterial community that in turn shape immune responses. We investigated the links between MHC class I and II gene diversity gut microbiome diversity and micro- (adenovirus, AdV) and macro- (helminth) parasite infection probabilities in a wild population of non-human primates, mouse lemurs of Madagascar. This setup encompasses a plethora of underlying interactions between parasites, microbes and adaptive immunity in natural populations. Both MHC classes explained shifts in microbiome composition and the effect was driven by a few select microbial taxa. Among them were three taxa (Odoribacter, Campylobacter and Prevotellaceae-UCG-001) which were in turn linked to AdV and helminth infection status, correlative evidence of the indirect effect of the MHC via the microbiome. Our study provides support for the coupled role of MHC diversity and microbial flora as contributing factors of parasite infection. Public Library of Science 2021-11-08 /pmc/articles/PMC8601626/ /pubmed/34748618 http://dx.doi.org/10.1371/journal.ppat.1009675 Text en © 2021 Montero et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Montero, B. Karina Wasimuddin, Schwensow, Nina Gillingham, Mark A. F. Ratovonamana, Yedidya R. Rakotondranary, S. Jacques Corman, Victor Drosten, Christian Ganzhorn, Jörg U. Sommer, Simone Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate |
title | Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate |
title_full | Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate |
title_fullStr | Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate |
title_full_unstemmed | Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate |
title_short | Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate |
title_sort | evidence of mhc class i and ii influencing viral and helminth infection via the microbiome in a non-human primate |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601626/ https://www.ncbi.nlm.nih.gov/pubmed/34748618 http://dx.doi.org/10.1371/journal.ppat.1009675 |
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