Selective Cdk9 inhibition resolves neutrophilic inflammation and enhances cardiac regeneration in larval zebrafish

Sustained neutrophilic inflammation is detrimental for cardiac repair and associated with adverse outcomes following myocardial infarction (MI). An attractive therapeutic strategy to treat MI is to reduce or remove infiltrating neutrophils to promote downstream reparative mechanisms. CDK9 inhibitor...

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Detalles Bibliográficos
Autores principales: Kaveh, Aryan, Bruton, Finnius A., Oremek, Magdalena E. M., Tucker, Carl S., Taylor, Jonathan M., Mullins, John J., Rossi, Adriano G., Denvir, Martin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Stem Cells and Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601713/
https://www.ncbi.nlm.nih.gov/pubmed/34523672
http://dx.doi.org/10.1242/dev.199636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601713/
https://www.ncbi.nlm.nih.gov/pubmed/34523672
http://dx.doi.org/10.1242/dev.199636

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