Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia

NOD-like receptor family, pyrin domain-containing protein 3 (NLRP3) inflammasome-mediated pyroptosis is a crucial event in the preeclamptic pathogenesis, tightly linked with the uteroplacental TLR4/NF-κB signaling. Trophoblastic glycometabolism reprogramming has now been noticed in the preeclampsia...

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Detalles Bibliográficos
Autores principales: Zhang, Yang, Liu, Weifang, Zhong, Yanqi, Li, Qi, Wu, Mengying, Yang, Liu, Liu, Xiaoxia, Zou, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601820/
https://www.ncbi.nlm.nih.gov/pubmed/34804360
http://dx.doi.org/10.1155/2021/1806344

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