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Hydrogen peroxide as an auxiliary treatment for COVID-19 in Brazil: a randomized double-blind clinical trial

OBJECTIVES: This study evaluated the effectiveness of hydrogen peroxide (H(2)O(2)) as mouthwash and nasal spray on symptom relief in coronavirus disease 2019 (COVID-19) patients. METHODS: Patients positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), who were treated in a hospit...

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Detalles Bibliográficos
Autores principales: Domênico, Marielle Bazzo Di, Collares, Kauê, dos Santos, Renan Brandenburg, Lenz, Ulysses, Antunes, Vinícius Picoli, Godinho, Vinicius Webber, Cesca, Henrique, Ponciano, Thales Henrique Jincziwski, Corazza, Pedro Henrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Epidemiology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602056/
https://www.ncbi.nlm.nih.gov/pubmed/34529913
http://dx.doi.org/10.4178/epih.e2021051
Descripción
Sumario:OBJECTIVES: This study evaluated the effectiveness of hydrogen peroxide (H(2)O(2)) as mouthwash and nasal spray on symptom relief in coronavirus disease 2019 (COVID-19) patients. METHODS: Patients positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), who were treated in a hospital or at home, and patients’ family members (not positive for SARS-CoV-2), were randomized into 2 groups: experimental (1% H(2)O(2) for gargling, 0.5% H(2)O(2) for nasal wash), and control. Patients gargled the solution 3 times a day, and applied the nasal spray twice a day, for a 7-day period. Family members received the same treatment as the treated COVID-19 patient. The researchers contacted patients every 2 days over an 8-day period. An average post-treatment interval of 8 days passed before testing family members. RESULTS: The most frequent symptoms on day 0 were cough, loss of taste, and hyposmia; there were no significant differences between groups, independent of the period. The symptom of dyspnea presented a significant difference between days 2 and 4 (p<0.05). Among family members, 86.0% had no antibodies, 2.3% had antibodies, and 11.6% had active infections (4 in the experimental group and 6 in the control group). The most frequent adverse effects in the H(2)O(2) group were a burning throat and nose. CONCLUSIONS: H(2)O(2) was not effective for the relief of COVID-19 symptoms and was associated with reports of transient adverse effects.