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Primary Yolk Sac Tumor in the Cerebellar Hemisphere: A Case Report and Literature Review of the Rare Tumor

Yolk sac tumor (YST) is one of rare malignant germ cell tumors (GCTs). Primary intracranial YST, also endodermal sinus tumor (EST), is a quite rare type of brain tumor. Here, we report a case of YST, review the relevant literature, and propose a treatment strategy for this rare tumor. A 6-year-old b...

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Autores principales: Wu, Na, Chen, Qiang, Chen, Meng, Ning, Jinbo, Peng, Shulei, Zhang, Taotao, Zhong, Wen, Duan, Song, Cheng, Chongjie, Xie, Yimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602065/
https://www.ncbi.nlm.nih.gov/pubmed/34804928
http://dx.doi.org/10.3389/fonc.2021.739733
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author Wu, Na
Chen, Qiang
Chen, Meng
Ning, Jinbo
Peng, Shulei
Zhang, Taotao
Zhong, Wen
Duan, Song
Cheng, Chongjie
Xie, Yimin
author_facet Wu, Na
Chen, Qiang
Chen, Meng
Ning, Jinbo
Peng, Shulei
Zhang, Taotao
Zhong, Wen
Duan, Song
Cheng, Chongjie
Xie, Yimin
author_sort Wu, Na
collection PubMed
description Yolk sac tumor (YST) is one of rare malignant germ cell tumors (GCTs). Primary intracranial YST, also endodermal sinus tumor (EST), is a quite rare type of brain tumor. Here, we report a case of YST, review the relevant literature, and propose a treatment strategy for this rare tumor. A 6-year-old boy initially manifested symptoms of dizziness and vomiting. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a large irregular oval tumor in the cerebellar hemisphere. We subtotally removed the tumor by microsurgery through the left suboccipital approach. Immunohistochemical staining showed that alpha fetoprotein (AFP) was positive and the Ki-67 proliferation index was high (60%), suggesting a germ cell tumor. After 3 months of follow-up, neither recurrence of tumor nor complications were found in the patient. The diagnosis of YST should be confirmed on the basis of clinical manifestations, neuroimaging and pathological findings. Gross total resection (GTR) is an ideal treatment for YST. However, due to the location of the tumor, GTR is usually difficult, and the rate of postoperative complications is high. This reported case shows that subtotal resection can be a good treatment strategy for YST.
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spelling pubmed-86020652021-11-20 Primary Yolk Sac Tumor in the Cerebellar Hemisphere: A Case Report and Literature Review of the Rare Tumor Wu, Na Chen, Qiang Chen, Meng Ning, Jinbo Peng, Shulei Zhang, Taotao Zhong, Wen Duan, Song Cheng, Chongjie Xie, Yimin Front Oncol Oncology Yolk sac tumor (YST) is one of rare malignant germ cell tumors (GCTs). Primary intracranial YST, also endodermal sinus tumor (EST), is a quite rare type of brain tumor. Here, we report a case of YST, review the relevant literature, and propose a treatment strategy for this rare tumor. A 6-year-old boy initially manifested symptoms of dizziness and vomiting. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a large irregular oval tumor in the cerebellar hemisphere. We subtotally removed the tumor by microsurgery through the left suboccipital approach. Immunohistochemical staining showed that alpha fetoprotein (AFP) was positive and the Ki-67 proliferation index was high (60%), suggesting a germ cell tumor. After 3 months of follow-up, neither recurrence of tumor nor complications were found in the patient. The diagnosis of YST should be confirmed on the basis of clinical manifestations, neuroimaging and pathological findings. Gross total resection (GTR) is an ideal treatment for YST. However, due to the location of the tumor, GTR is usually difficult, and the rate of postoperative complications is high. This reported case shows that subtotal resection can be a good treatment strategy for YST. Frontiers Media S.A. 2021-11-05 /pmc/articles/PMC8602065/ /pubmed/34804928 http://dx.doi.org/10.3389/fonc.2021.739733 Text en Copyright © 2021 Wu, Chen, Chen, Ning, Peng, Zhang, Zhong, Duan, Cheng and Xie https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wu, Na
Chen, Qiang
Chen, Meng
Ning, Jinbo
Peng, Shulei
Zhang, Taotao
Zhong, Wen
Duan, Song
Cheng, Chongjie
Xie, Yimin
Primary Yolk Sac Tumor in the Cerebellar Hemisphere: A Case Report and Literature Review of the Rare Tumor
title Primary Yolk Sac Tumor in the Cerebellar Hemisphere: A Case Report and Literature Review of the Rare Tumor
title_full Primary Yolk Sac Tumor in the Cerebellar Hemisphere: A Case Report and Literature Review of the Rare Tumor
title_fullStr Primary Yolk Sac Tumor in the Cerebellar Hemisphere: A Case Report and Literature Review of the Rare Tumor
title_full_unstemmed Primary Yolk Sac Tumor in the Cerebellar Hemisphere: A Case Report and Literature Review of the Rare Tumor
title_short Primary Yolk Sac Tumor in the Cerebellar Hemisphere: A Case Report and Literature Review of the Rare Tumor
title_sort primary yolk sac tumor in the cerebellar hemisphere: a case report and literature review of the rare tumor
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602065/
https://www.ncbi.nlm.nih.gov/pubmed/34804928
http://dx.doi.org/10.3389/fonc.2021.739733
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