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Physiologically Based Pharmacokinetic Modeling of Rosuvastatin to Predict Transporter-Mediated Drug-Drug Interactions

PURPOSE: To build a physiologically based pharmacokinetic (PBPK) model of the clinical OATP1B1/OATP1B3/BCRP victim drug rosuvastatin for the investigation and prediction of its transporter-mediated drug-drug interactions (DDIs). METHODS: The Rosuvastatin model was developed using the open-source PBP...

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Detalles Bibliográficos
Autores principales:	Hanke, Nina, Gómez-Mantilla, José David, Ishiguro, Naoki, Stopfer, Peter, Nock, Valerie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602162/ https://www.ncbi.nlm.nih.gov/pubmed/34664206 http://dx.doi.org/10.1007/s11095-021-03109-6

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