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Prognostic value of the systemic immune-inflammation index in non-muscle invasive bladder cancer
PURPOSE: We assessed the prognostic value of systemic immune-inflammation index (SII) to refine risk stratification of the heterogeneous spectrum of patients with non-muscle-invasive bladder cancer (NMIBC) METHODS: In this multi-institutional cohort, preoperative blood-based SII was retrospectively...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602174/ https://www.ncbi.nlm.nih.gov/pubmed/34143284 http://dx.doi.org/10.1007/s00345-021-03740-3 |
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author | Katayama, Satoshi Mori, Keiichiro Pradere, Benjamin Laukhtina, Ekaterina Schuettfort, Victor M. Quhal, Fahad Motlagh, Reza Sari Mostafaei, Hadi Grossmann, Nico C. Rajwa, Pawel Moschini, Marco Mathieu, Romain Abufaraj, Mohammad D’Andrea, David Compérat, Eva Haydter, Martin Egawa, Shin Nasu, Yasutomo Shariat, Shahrokh F. |
author_facet | Katayama, Satoshi Mori, Keiichiro Pradere, Benjamin Laukhtina, Ekaterina Schuettfort, Victor M. Quhal, Fahad Motlagh, Reza Sari Mostafaei, Hadi Grossmann, Nico C. Rajwa, Pawel Moschini, Marco Mathieu, Romain Abufaraj, Mohammad D’Andrea, David Compérat, Eva Haydter, Martin Egawa, Shin Nasu, Yasutomo Shariat, Shahrokh F. |
author_sort | Katayama, Satoshi |
collection | PubMed |
description | PURPOSE: We assessed the prognostic value of systemic immune-inflammation index (SII) to refine risk stratification of the heterogeneous spectrum of patients with non-muscle-invasive bladder cancer (NMIBC) METHODS: In this multi-institutional cohort, preoperative blood-based SII was retrospectively assessed in 1117 patients with NMIBC who underwent transurethral resection of bladder (TURB) between 1996 and 2007. The optimal cut-off value of SII was determined as 580 using the best Youden index. Cox regression analyses were performed. The concordance index (C-index) and decision curve analysis (DCA) were used to assess the discrimination of the predictive models. RESULTS: Overall, 309 (28%) patients had high SII. On multivariable analyses, high SII was significantly associated with worse PFS (hazard ratio [HR] 1.84; 95% confidence interval [CI] 1.23–2.77; P = 0.003) and CSS (HR 2.53; 95% CI 1.42–4.48; P = 0.001). Subgroup analyses, according to the European Association of Urology guidelines, demonstrated the main prognostic impact of high SII, with regards to PFS (HR 3.39; 95%CI 1.57–7.31; P = 0.002) and CSS (HR 4.93; 95% CI 1.70–14.3; P = 0.005), in patients with intermediate-risk group; addition of SII to the standard predictive model improved its discrimination ability both on C-index (6% and 12%, respectively) and DCA. In exploratory intergroup analyses of patients with intermediate-risk, the improved discrimination ability was retained the prediction of PFS and CSS. CONCLUSION: Preoperative SII seems to identify NMIBC patients who have a worse disease and prognosis. Such easily available and cheap standard biomarkers may help refine the decision-making process regarding adjuvant treatment in patients with intermediate-risk NMIBC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00345-021-03740-3. |
format | Online Article Text |
id | pubmed-8602174 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-86021742021-12-03 Prognostic value of the systemic immune-inflammation index in non-muscle invasive bladder cancer Katayama, Satoshi Mori, Keiichiro Pradere, Benjamin Laukhtina, Ekaterina Schuettfort, Victor M. Quhal, Fahad Motlagh, Reza Sari Mostafaei, Hadi Grossmann, Nico C. Rajwa, Pawel Moschini, Marco Mathieu, Romain Abufaraj, Mohammad D’Andrea, David Compérat, Eva Haydter, Martin Egawa, Shin Nasu, Yasutomo Shariat, Shahrokh F. World J Urol Original Article PURPOSE: We assessed the prognostic value of systemic immune-inflammation index (SII) to refine risk stratification of the heterogeneous spectrum of patients with non-muscle-invasive bladder cancer (NMIBC) METHODS: In this multi-institutional cohort, preoperative blood-based SII was retrospectively assessed in 1117 patients with NMIBC who underwent transurethral resection of bladder (TURB) between 1996 and 2007. The optimal cut-off value of SII was determined as 580 using the best Youden index. Cox regression analyses were performed. The concordance index (C-index) and decision curve analysis (DCA) were used to assess the discrimination of the predictive models. RESULTS: Overall, 309 (28%) patients had high SII. On multivariable analyses, high SII was significantly associated with worse PFS (hazard ratio [HR] 1.84; 95% confidence interval [CI] 1.23–2.77; P = 0.003) and CSS (HR 2.53; 95% CI 1.42–4.48; P = 0.001). Subgroup analyses, according to the European Association of Urology guidelines, demonstrated the main prognostic impact of high SII, with regards to PFS (HR 3.39; 95%CI 1.57–7.31; P = 0.002) and CSS (HR 4.93; 95% CI 1.70–14.3; P = 0.005), in patients with intermediate-risk group; addition of SII to the standard predictive model improved its discrimination ability both on C-index (6% and 12%, respectively) and DCA. In exploratory intergroup analyses of patients with intermediate-risk, the improved discrimination ability was retained the prediction of PFS and CSS. CONCLUSION: Preoperative SII seems to identify NMIBC patients who have a worse disease and prognosis. Such easily available and cheap standard biomarkers may help refine the decision-making process regarding adjuvant treatment in patients with intermediate-risk NMIBC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00345-021-03740-3. Springer Berlin Heidelberg 2021-06-18 2021 /pmc/articles/PMC8602174/ /pubmed/34143284 http://dx.doi.org/10.1007/s00345-021-03740-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Katayama, Satoshi Mori, Keiichiro Pradere, Benjamin Laukhtina, Ekaterina Schuettfort, Victor M. Quhal, Fahad Motlagh, Reza Sari Mostafaei, Hadi Grossmann, Nico C. Rajwa, Pawel Moschini, Marco Mathieu, Romain Abufaraj, Mohammad D’Andrea, David Compérat, Eva Haydter, Martin Egawa, Shin Nasu, Yasutomo Shariat, Shahrokh F. Prognostic value of the systemic immune-inflammation index in non-muscle invasive bladder cancer |
title | Prognostic value of the systemic immune-inflammation index in non-muscle invasive bladder cancer |
title_full | Prognostic value of the systemic immune-inflammation index in non-muscle invasive bladder cancer |
title_fullStr | Prognostic value of the systemic immune-inflammation index in non-muscle invasive bladder cancer |
title_full_unstemmed | Prognostic value of the systemic immune-inflammation index in non-muscle invasive bladder cancer |
title_short | Prognostic value of the systemic immune-inflammation index in non-muscle invasive bladder cancer |
title_sort | prognostic value of the systemic immune-inflammation index in non-muscle invasive bladder cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602174/ https://www.ncbi.nlm.nih.gov/pubmed/34143284 http://dx.doi.org/10.1007/s00345-021-03740-3 |
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