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Novel Quantification of Extracellular Vesicles with Unaltered Surface Membranes Using an Internalized Oligonucleotide Tracer and Applied Pharmacokinetic Multiple Compartment Modeling

PURPOSE: We developed an accessible method for labeling small extracellular vesicles (sEVs) without disrupting endogenous ligands. Using labeled sEVs administered to conscious rats, we developed a multiple compartment pharmacokinetic model to identify potential differences in the disposition of sEVs...

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Detalles Bibliográficos
Autores principales:	De Luca, Thomas, Stratford, Robert E., Edwards, Madison E., Ferreira, Christina R., Benson, Eric A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602176/ https://www.ncbi.nlm.nih.gov/pubmed/34671921 http://dx.doi.org/10.1007/s11095-021-03102-z

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