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Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka

Neonicotinoids are systemic insecticides used since the 1990’s , that possess renal tubular toxicity. We conducted a field-based descriptive study in the North Central Dry-zone of Sri Lanka, where chronic kidney disease (CKD) of unknown etiology has been increasing since the 1990’s. To elucidate the...

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Autores principales: Taira, Kumiko, Kawakami, Tomonori, Weragoda, Sujithra Kaushaliya, Herath, H. M. Ayala S., Ikenaka, Yoshinori, Fujioka, Kazutoshi, Hemachandra, Madhubhani, Pallewatta, Nirmalie, Aoyama, Yoshiko, Ishizuka, Mayumi, Bonmatin, Jean-Marc, Komori, Makiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602289/
https://www.ncbi.nlm.nih.gov/pubmed/34795341
http://dx.doi.org/10.1038/s41598-021-01732-2
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author Taira, Kumiko
Kawakami, Tomonori
Weragoda, Sujithra Kaushaliya
Herath, H. M. Ayala S.
Ikenaka, Yoshinori
Fujioka, Kazutoshi
Hemachandra, Madhubhani
Pallewatta, Nirmalie
Aoyama, Yoshiko
Ishizuka, Mayumi
Bonmatin, Jean-Marc
Komori, Makiko
author_facet Taira, Kumiko
Kawakami, Tomonori
Weragoda, Sujithra Kaushaliya
Herath, H. M. Ayala S.
Ikenaka, Yoshinori
Fujioka, Kazutoshi
Hemachandra, Madhubhani
Pallewatta, Nirmalie
Aoyama, Yoshiko
Ishizuka, Mayumi
Bonmatin, Jean-Marc
Komori, Makiko
author_sort Taira, Kumiko
collection PubMed
description Neonicotinoids are systemic insecticides used since the 1990’s , that possess renal tubular toxicity. We conducted a field-based descriptive study in the North Central Dry-zone of Sri Lanka, where chronic kidney disease (CKD) of unknown etiology has been increasing since the 1990’s. To elucidate the relationship between renal tubular dysfunctions and urinary neonicotinoids concentrations, we collected spot urine samples from15 CKD patients, 15 family members, and 62 neighbors in 2015, analyzed two renal tubular biomarkers, Cystatin-C and L-FABP, quantified seven neonicotinoids and a metabolite N-desmethyl-acetamiprid by LC–MS/MS; and we investigated their symptoms using a questionnaire. Cystatin-C and L-FABP had a positive correlation (p < 0.001). N-Desmethyl-acetamiprid was detected in 92.4% of the urine samples, followed by dinotefuran (17.4%), thiamethoxam (17.4%), clothianidin (9.8%), thiacloprid and imidacloprid. Dinotefuran and thiacloprid have never been registered in Sri Lanka. In High Cystatin-C group (> 70 μg/gCre, n = 7), higher urinary concentration of dinotefuran (p = 0.009), and in Zero Cystatin-C group (< LOQ, n = 7), higher N-desmethyl-acetamiprid (p = 0.013), dinotefuran (p = 0.049), and thiacloprid (p = 0.035), and more complaints of chest pains, stomachache, skin eruption and diarrhea (p < 0.05) were found than in Normal Cystatin-C group (n = 78). Urinary neonicotinoids may be one of the potential risk factors for renal tubular dysfunction in this area.
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spelling pubmed-86022892021-11-19 Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka Taira, Kumiko Kawakami, Tomonori Weragoda, Sujithra Kaushaliya Herath, H. M. Ayala S. Ikenaka, Yoshinori Fujioka, Kazutoshi Hemachandra, Madhubhani Pallewatta, Nirmalie Aoyama, Yoshiko Ishizuka, Mayumi Bonmatin, Jean-Marc Komori, Makiko Sci Rep Article Neonicotinoids are systemic insecticides used since the 1990’s , that possess renal tubular toxicity. We conducted a field-based descriptive study in the North Central Dry-zone of Sri Lanka, where chronic kidney disease (CKD) of unknown etiology has been increasing since the 1990’s. To elucidate the relationship between renal tubular dysfunctions and urinary neonicotinoids concentrations, we collected spot urine samples from15 CKD patients, 15 family members, and 62 neighbors in 2015, analyzed two renal tubular biomarkers, Cystatin-C and L-FABP, quantified seven neonicotinoids and a metabolite N-desmethyl-acetamiprid by LC–MS/MS; and we investigated their symptoms using a questionnaire. Cystatin-C and L-FABP had a positive correlation (p < 0.001). N-Desmethyl-acetamiprid was detected in 92.4% of the urine samples, followed by dinotefuran (17.4%), thiamethoxam (17.4%), clothianidin (9.8%), thiacloprid and imidacloprid. Dinotefuran and thiacloprid have never been registered in Sri Lanka. In High Cystatin-C group (> 70 μg/gCre, n = 7), higher urinary concentration of dinotefuran (p = 0.009), and in Zero Cystatin-C group (< LOQ, n = 7), higher N-desmethyl-acetamiprid (p = 0.013), dinotefuran (p = 0.049), and thiacloprid (p = 0.035), and more complaints of chest pains, stomachache, skin eruption and diarrhea (p < 0.05) were found than in Normal Cystatin-C group (n = 78). Urinary neonicotinoids may be one of the potential risk factors for renal tubular dysfunction in this area. Nature Publishing Group UK 2021-11-18 /pmc/articles/PMC8602289/ /pubmed/34795341 http://dx.doi.org/10.1038/s41598-021-01732-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Taira, Kumiko
Kawakami, Tomonori
Weragoda, Sujithra Kaushaliya
Herath, H. M. Ayala S.
Ikenaka, Yoshinori
Fujioka, Kazutoshi
Hemachandra, Madhubhani
Pallewatta, Nirmalie
Aoyama, Yoshiko
Ishizuka, Mayumi
Bonmatin, Jean-Marc
Komori, Makiko
Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka
title Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka
title_full Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka
title_fullStr Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka
title_full_unstemmed Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka
title_short Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka
title_sort urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in dry-zone of sri lanka
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602289/
https://www.ncbi.nlm.nih.gov/pubmed/34795341
http://dx.doi.org/10.1038/s41598-021-01732-2
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