G3BP1 inhibits Cul3(SPOP) to amplify AR signaling and promote prostate cancer

SPOP, an E3 ubiquitin ligase, acts as a prostate-specific tumor suppressor with several key substrates mediating oncogenic function. However, the mechanisms underlying SPOP regulation are largely unknown. Here, we have identified G3BP1 as an interactor of SPOP and functions as a competitive inhibito...

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Detalles Bibliográficos
Autores principales: Mukhopadhyay, Chandrani, Yang, Chenyi, Xu, Limei, Liu, Deli, Wang, Yu, Huang, Dennis, Deonarine, Lesa Dayal, Cyrta, Joanna, Davicioni, Elai, Sboner, Andrea, Robinson, Brian. D., Chinnaiyan, Arul M., Rubin, Mark A., Barbieri, Christopher E., Zhou, Pengbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602290/
https://www.ncbi.nlm.nih.gov/pubmed/34795264
http://dx.doi.org/10.1038/s41467-021-27024-x

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