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Inherited Tolerance in Cattle to the Apicomplexan Protozoan Theileria parva is Associated with Decreased Proliferation of Parasite-Infected Lymphocytes

Theileria parva is the causative agent of East Coast fever and Corridor disease, which are fatal, economically important diseases of cattle in eastern, central and southern Africa. Improved methods of control of the diseases are urgently required. The parasite transforms host lymphocytes, resulting...

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Autores principales: Latre de Late, Perle, Cook, Elizabeth A. J., Wragg, David, Poole, E. Jane, Ndambuki, Gideon, Miyunga, Antoinette Aluoch, Chepkwony, Maurine C., Mwaura, Stephen, Ndiwa, Nicholas, Prettejohn, Giles, Sitt, Tatjana, Van Aardt, Richard, Morrison, W. Ivan, Prendergast, James G. D., Toye, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602341/
https://www.ncbi.nlm.nih.gov/pubmed/34804994
http://dx.doi.org/10.3389/fcimb.2021.751671
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author Latre de Late, Perle
Cook, Elizabeth A. J.
Wragg, David
Poole, E. Jane
Ndambuki, Gideon
Miyunga, Antoinette Aluoch
Chepkwony, Maurine C.
Mwaura, Stephen
Ndiwa, Nicholas
Prettejohn, Giles
Sitt, Tatjana
Van Aardt, Richard
Morrison, W. Ivan
Prendergast, James G. D.
Toye, Philip
author_facet Latre de Late, Perle
Cook, Elizabeth A. J.
Wragg, David
Poole, E. Jane
Ndambuki, Gideon
Miyunga, Antoinette Aluoch
Chepkwony, Maurine C.
Mwaura, Stephen
Ndiwa, Nicholas
Prettejohn, Giles
Sitt, Tatjana
Van Aardt, Richard
Morrison, W. Ivan
Prendergast, James G. D.
Toye, Philip
author_sort Latre de Late, Perle
collection PubMed
description Theileria parva is the causative agent of East Coast fever and Corridor disease, which are fatal, economically important diseases of cattle in eastern, central and southern Africa. Improved methods of control of the diseases are urgently required. The parasite transforms host lymphocytes, resulting in a rapid, clonal expansion of infected cells. Resistance to the disease has long been reported in cattle from T. parva-endemic areas. We reveal here that first- and second-generation descendants of a single Bos indicus bull survived severe challenge with T. parva, (overall survival rate 57.3% compared to 8.7% for unrelated animals) in a series of five field studies. Tolerant cattle displayed a delayed and less severe parasitosis and febrile response than unrelated animals. The in vitro proliferation of cells from surviving cattle was much reduced compared to those from animals that succumbed to infection. Additionally, some pro-inflammatory cytokines such as IL1β, IL6, TNFα or TGFβ which are usually strongly expressed in susceptible animals and are known to regulate cell growth or motility, remain low in tolerant animals. This correlates with the reduced proliferation and less severe clinical reactions observed in tolerant cattle. The results show for the first time that the inherited tolerance to T. parva is associated with decreased proliferation of infected lymphocytes. The results are discussed in terms of whether the reduced proliferation is the result of a perturbation of the transformation mechanism induced in infected cells or is due to an innate immune response present in the tolerant cattle.
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spelling pubmed-86023412021-11-20 Inherited Tolerance in Cattle to the Apicomplexan Protozoan Theileria parva is Associated with Decreased Proliferation of Parasite-Infected Lymphocytes Latre de Late, Perle Cook, Elizabeth A. J. Wragg, David Poole, E. Jane Ndambuki, Gideon Miyunga, Antoinette Aluoch Chepkwony, Maurine C. Mwaura, Stephen Ndiwa, Nicholas Prettejohn, Giles Sitt, Tatjana Van Aardt, Richard Morrison, W. Ivan Prendergast, James G. D. Toye, Philip Front Cell Infect Microbiol Cellular and Infection Microbiology Theileria parva is the causative agent of East Coast fever and Corridor disease, which are fatal, economically important diseases of cattle in eastern, central and southern Africa. Improved methods of control of the diseases are urgently required. The parasite transforms host lymphocytes, resulting in a rapid, clonal expansion of infected cells. Resistance to the disease has long been reported in cattle from T. parva-endemic areas. We reveal here that first- and second-generation descendants of a single Bos indicus bull survived severe challenge with T. parva, (overall survival rate 57.3% compared to 8.7% for unrelated animals) in a series of five field studies. Tolerant cattle displayed a delayed and less severe parasitosis and febrile response than unrelated animals. The in vitro proliferation of cells from surviving cattle was much reduced compared to those from animals that succumbed to infection. Additionally, some pro-inflammatory cytokines such as IL1β, IL6, TNFα or TGFβ which are usually strongly expressed in susceptible animals and are known to regulate cell growth or motility, remain low in tolerant animals. This correlates with the reduced proliferation and less severe clinical reactions observed in tolerant cattle. The results show for the first time that the inherited tolerance to T. parva is associated with decreased proliferation of infected lymphocytes. The results are discussed in terms of whether the reduced proliferation is the result of a perturbation of the transformation mechanism induced in infected cells or is due to an innate immune response present in the tolerant cattle. Frontiers Media S.A. 2021-11-05 /pmc/articles/PMC8602341/ /pubmed/34804994 http://dx.doi.org/10.3389/fcimb.2021.751671 Text en Copyright © 2021 Latre de Late, Cook, Wragg, Poole, Ndambuki, Miyunga, Chepkwony, Mwaura, Ndiwa, Prettejohn, Sitt, Van Aardt, Morrison, Prendergast and Toye https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Latre de Late, Perle
Cook, Elizabeth A. J.
Wragg, David
Poole, E. Jane
Ndambuki, Gideon
Miyunga, Antoinette Aluoch
Chepkwony, Maurine C.
Mwaura, Stephen
Ndiwa, Nicholas
Prettejohn, Giles
Sitt, Tatjana
Van Aardt, Richard
Morrison, W. Ivan
Prendergast, James G. D.
Toye, Philip
Inherited Tolerance in Cattle to the Apicomplexan Protozoan Theileria parva is Associated with Decreased Proliferation of Parasite-Infected Lymphocytes
title Inherited Tolerance in Cattle to the Apicomplexan Protozoan Theileria parva is Associated with Decreased Proliferation of Parasite-Infected Lymphocytes
title_full Inherited Tolerance in Cattle to the Apicomplexan Protozoan Theileria parva is Associated with Decreased Proliferation of Parasite-Infected Lymphocytes
title_fullStr Inherited Tolerance in Cattle to the Apicomplexan Protozoan Theileria parva is Associated with Decreased Proliferation of Parasite-Infected Lymphocytes
title_full_unstemmed Inherited Tolerance in Cattle to the Apicomplexan Protozoan Theileria parva is Associated with Decreased Proliferation of Parasite-Infected Lymphocytes
title_short Inherited Tolerance in Cattle to the Apicomplexan Protozoan Theileria parva is Associated with Decreased Proliferation of Parasite-Infected Lymphocytes
title_sort inherited tolerance in cattle to the apicomplexan protozoan theileria parva is associated with decreased proliferation of parasite-infected lymphocytes
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602341/
https://www.ncbi.nlm.nih.gov/pubmed/34804994
http://dx.doi.org/10.3389/fcimb.2021.751671
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