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Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice
Chronic stress induces adaptive changes in the brain via the cumulative action of glucocorticoids, which is associated with mood disorders. Here we show that repeated daily five-minute restraint resolves pre-existing stress-induced depressive-like behavior in mice. Repeated injection of glucocortico...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602389/ https://www.ncbi.nlm.nih.gov/pubmed/34795225 http://dx.doi.org/10.1038/s41467-021-26968-4 |
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author | Lee, Eun-Hwa Park, Jin-Young Kwon, Hye-Jin Han, Pyung-Lim |
author_facet | Lee, Eun-Hwa Park, Jin-Young Kwon, Hye-Jin Han, Pyung-Lim |
author_sort | Lee, Eun-Hwa |
collection | PubMed |
description | Chronic stress induces adaptive changes in the brain via the cumulative action of glucocorticoids, which is associated with mood disorders. Here we show that repeated daily five-minute restraint resolves pre-existing stress-induced depressive-like behavior in mice. Repeated injection of glucocorticoids in low doses mimics the anti-depressive effects of short-term stress. Repeated exposure to short-term stress and injection of glucocorticoids activate neurons in largely overlapping regions of the brain, as shown by c-Fos staining, and reverse distinct stress-induced gene expression profiles. Chemogenetic inhibition of neurons in the prelimbic cortex projecting to the nucleus accumbens, basolateral amygdala, or bed nucleus of the stria terminalis results in anti-depressive effects similarly to short-term stress exposure, while only inhibition of neurons in the prelimbic cortex projecting to the bed nucleus of the stria terminalis rescues defective glucocorticoid release. In summary, we show that short-term stress can reverse adaptively altered stress gains and resolve stress-induced depressive-like behavior. |
format | Online Article Text |
id | pubmed-8602389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-86023892021-12-03 Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice Lee, Eun-Hwa Park, Jin-Young Kwon, Hye-Jin Han, Pyung-Lim Nat Commun Article Chronic stress induces adaptive changes in the brain via the cumulative action of glucocorticoids, which is associated with mood disorders. Here we show that repeated daily five-minute restraint resolves pre-existing stress-induced depressive-like behavior in mice. Repeated injection of glucocorticoids in low doses mimics the anti-depressive effects of short-term stress. Repeated exposure to short-term stress and injection of glucocorticoids activate neurons in largely overlapping regions of the brain, as shown by c-Fos staining, and reverse distinct stress-induced gene expression profiles. Chemogenetic inhibition of neurons in the prelimbic cortex projecting to the nucleus accumbens, basolateral amygdala, or bed nucleus of the stria terminalis results in anti-depressive effects similarly to short-term stress exposure, while only inhibition of neurons in the prelimbic cortex projecting to the bed nucleus of the stria terminalis rescues defective glucocorticoid release. In summary, we show that short-term stress can reverse adaptively altered stress gains and resolve stress-induced depressive-like behavior. Nature Publishing Group UK 2021-11-18 /pmc/articles/PMC8602389/ /pubmed/34795225 http://dx.doi.org/10.1038/s41467-021-26968-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lee, Eun-Hwa Park, Jin-Young Kwon, Hye-Jin Han, Pyung-Lim Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice |
title | Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice |
title_full | Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice |
title_fullStr | Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice |
title_full_unstemmed | Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice |
title_short | Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice |
title_sort | repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602389/ https://www.ncbi.nlm.nih.gov/pubmed/34795225 http://dx.doi.org/10.1038/s41467-021-26968-4 |
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