Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma

Cutaneous T cell lymphomas (CTCL) are rare but aggressive cancers without effective treatments. While a subset of patients derive benefit from PD-1 blockade, there is a critically unmet need for predictive biomarkers of response. Herein, we perform CODEX multiplexed tissue imaging and RNA sequencing...

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Detalles Bibliográficos
Autores principales: Phillips, Darci, Matusiak, Magdalena, Gutierrez, Belén Rivero, Bhate, Salil S., Barlow, Graham L., Jiang, Sizun, Demeter, Janos, Smythe, Kimberly S., Pierce, Robert H., Fling, Steven P., Ramchurren, Nirasha, Cheever, Martin A., Goltsev, Yury, West, Robert B., Khodadoust, Michael S., Kim, Youn H., Schürch, Christian M., Nolan, Garry P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602403/
https://www.ncbi.nlm.nih.gov/pubmed/34795254
http://dx.doi.org/10.1038/s41467-021-26974-6

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