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Elevated Neddylation Pathway Promotes Th2 Cells Infiltration by Transactivating STAT5A in Hepatocellular Carcinoma

Neddylation is a process in which a ubiquitin-like molecule NEDD8 is conjugated to a lysine residue of the substrate protein via successive enzymatic cascade reactions. Inactivation of neddylation pathway triggers tumor cell apoptosis or senescence to suppress the tumor growth. So far, there has bee...

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Detalles Bibliográficos
Autores principales: Zhou, Lisha, Zhang, Luyi, Chen, Siyuan, Sun, Dongsheng, Qu, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602568/
https://www.ncbi.nlm.nih.gov/pubmed/34804916
http://dx.doi.org/10.3389/fonc.2021.709170