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Clinical and Preclinical Single-Dose Pharmacokinetics of VIR-2218, an RNAi Therapeutic Targeting HBV Infection

BACKGROUND AND OBJECTIVE: VIR-2218 is an investigational N-acetylgalactosamine–conjugated RNA interference therapeutic in development for chronic hepatitis B virus (HBV) infection. VIR-2218 was designed to silence HBV transcripts across all genotypes and uses Enhanced Stabilization Chemistry Plus (E...

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Detalles Bibliográficos
Autores principales:	Gupta, Sneha V., Fanget, Marie C., MacLauchlin, Christopher, Clausen, Valerie A., Li, Jing, Cloutier, Daniel, Shen, Ling, Robbie, Gabriel J., Mogalian, Erik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602582/ https://www.ncbi.nlm.nih.gov/pubmed/34741731 http://dx.doi.org/10.1007/s40268-021-00369-w

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