Cargando…
Effect and Management of Excess Weight in the Context of Fertility-Sparing Treatments in Patients With Atypical Endometrial Hyperplasia and Endometrial Cancer: Eight-Year Experience of 227 Cases
OBJECTIVE: To investigate the oncologic and reproductive outcomes of fertility-sparing treatments (FSTs) in atypical endometrial hyperplasia (AEH) and endometrial cancer (EC) patients with excess weight (EW). METHODS: This retrospective study comprised patients with AEH or EC who achieved a complete...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602817/ https://www.ncbi.nlm.nih.gov/pubmed/34804936 http://dx.doi.org/10.3389/fonc.2021.749881 |
_version_ | 1784601640146305024 |
---|---|
author | Shan, Ying Qin, Meng Yin, Jie Cai, Yan Li, Yan Gu, Yu Wang, Wei Wang, Yong-xue Chen, Jia-yu Jin, Ying Pan, Ling-ya |
author_facet | Shan, Ying Qin, Meng Yin, Jie Cai, Yan Li, Yan Gu, Yu Wang, Wei Wang, Yong-xue Chen, Jia-yu Jin, Ying Pan, Ling-ya |
author_sort | Shan, Ying |
collection | PubMed |
description | OBJECTIVE: To investigate the oncologic and reproductive outcomes of fertility-sparing treatments (FSTs) in atypical endometrial hyperplasia (AEH) and endometrial cancer (EC) patients with excess weight (EW). METHODS: This retrospective study comprised patients with AEH or EC who achieved a complete response (CR) after FST from 2010 to 2018. The clinical characteristics, oncological and reproductive outcomes were compared between the excess weight (EW) group (body mass index (BMI)≥25 kg/m(2)) and normal weight (NW) group (BMI<25 kg/m(2)). The risk factors associated with recurrence and unsuccessful pregnancy in patients with EW were analyzed. RESULTS: Overall, 227 patients were enrolled, including 139 (61.2%) in EW group and 88 (38.8%) in NW group. In patients with EW, the pregnancy rate, the live birth rate and the relapse rate were 29.8%, 23.4%, and 30.9%, respectively. In patients with NW, these rates were 61.1%, 47.2%, and 31.8%, respectively. No significant differences were observed in the time to remission (P=0.865) and disease-free survival (DFS) (P=0.750). Patients in NW group achieved a better pregnancy rate than patients in the EW group (P=0.034). The patients with EW using ovulation induction to increase fertility tended to have a shorter time to pregnancy (P=0.042). However, no significant risk factors associated with unsuccessful pregnancy were identified after the multivariate analysis. In terms of DFS, the combination of gonadotropin-releasing hormone agonist (GnRH-a) and LNG-IUD was better for patients with EW than GnRH-a or oral progestin therapy alone (P=0.044, adjusted hazard ratio (HR)=0.432, 95% confidence interval (CI): 0.152-1.229), especially for patients with EW diagnosed with EC (P=0.032). CONCLUSION: FSTs for overweight and obese patients should be more individualized. GnRH-a and/or LNG-IUD may be options prior to FSTs in patients with EW. Further prospective studies are needed. |
format | Online Article Text |
id | pubmed-8602817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86028172021-11-20 Effect and Management of Excess Weight in the Context of Fertility-Sparing Treatments in Patients With Atypical Endometrial Hyperplasia and Endometrial Cancer: Eight-Year Experience of 227 Cases Shan, Ying Qin, Meng Yin, Jie Cai, Yan Li, Yan Gu, Yu Wang, Wei Wang, Yong-xue Chen, Jia-yu Jin, Ying Pan, Ling-ya Front Oncol Oncology OBJECTIVE: To investigate the oncologic and reproductive outcomes of fertility-sparing treatments (FSTs) in atypical endometrial hyperplasia (AEH) and endometrial cancer (EC) patients with excess weight (EW). METHODS: This retrospective study comprised patients with AEH or EC who achieved a complete response (CR) after FST from 2010 to 2018. The clinical characteristics, oncological and reproductive outcomes were compared between the excess weight (EW) group (body mass index (BMI)≥25 kg/m(2)) and normal weight (NW) group (BMI<25 kg/m(2)). The risk factors associated with recurrence and unsuccessful pregnancy in patients with EW were analyzed. RESULTS: Overall, 227 patients were enrolled, including 139 (61.2%) in EW group and 88 (38.8%) in NW group. In patients with EW, the pregnancy rate, the live birth rate and the relapse rate were 29.8%, 23.4%, and 30.9%, respectively. In patients with NW, these rates were 61.1%, 47.2%, and 31.8%, respectively. No significant differences were observed in the time to remission (P=0.865) and disease-free survival (DFS) (P=0.750). Patients in NW group achieved a better pregnancy rate than patients in the EW group (P=0.034). The patients with EW using ovulation induction to increase fertility tended to have a shorter time to pregnancy (P=0.042). However, no significant risk factors associated with unsuccessful pregnancy were identified after the multivariate analysis. In terms of DFS, the combination of gonadotropin-releasing hormone agonist (GnRH-a) and LNG-IUD was better for patients with EW than GnRH-a or oral progestin therapy alone (P=0.044, adjusted hazard ratio (HR)=0.432, 95% confidence interval (CI): 0.152-1.229), especially for patients with EW diagnosed with EC (P=0.032). CONCLUSION: FSTs for overweight and obese patients should be more individualized. GnRH-a and/or LNG-IUD may be options prior to FSTs in patients with EW. Further prospective studies are needed. Frontiers Media S.A. 2021-11-05 /pmc/articles/PMC8602817/ /pubmed/34804936 http://dx.doi.org/10.3389/fonc.2021.749881 Text en Copyright © 2021 Shan, Qin, Yin, Cai, Li, Gu, Wang, Wang, Chen, Jin and Pan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Shan, Ying Qin, Meng Yin, Jie Cai, Yan Li, Yan Gu, Yu Wang, Wei Wang, Yong-xue Chen, Jia-yu Jin, Ying Pan, Ling-ya Effect and Management of Excess Weight in the Context of Fertility-Sparing Treatments in Patients With Atypical Endometrial Hyperplasia and Endometrial Cancer: Eight-Year Experience of 227 Cases |
title | Effect and Management of Excess Weight in the Context of Fertility-Sparing Treatments in Patients With Atypical Endometrial Hyperplasia and Endometrial Cancer: Eight-Year Experience of 227 Cases |
title_full | Effect and Management of Excess Weight in the Context of Fertility-Sparing Treatments in Patients With Atypical Endometrial Hyperplasia and Endometrial Cancer: Eight-Year Experience of 227 Cases |
title_fullStr | Effect and Management of Excess Weight in the Context of Fertility-Sparing Treatments in Patients With Atypical Endometrial Hyperplasia and Endometrial Cancer: Eight-Year Experience of 227 Cases |
title_full_unstemmed | Effect and Management of Excess Weight in the Context of Fertility-Sparing Treatments in Patients With Atypical Endometrial Hyperplasia and Endometrial Cancer: Eight-Year Experience of 227 Cases |
title_short | Effect and Management of Excess Weight in the Context of Fertility-Sparing Treatments in Patients With Atypical Endometrial Hyperplasia and Endometrial Cancer: Eight-Year Experience of 227 Cases |
title_sort | effect and management of excess weight in the context of fertility-sparing treatments in patients with atypical endometrial hyperplasia and endometrial cancer: eight-year experience of 227 cases |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602817/ https://www.ncbi.nlm.nih.gov/pubmed/34804936 http://dx.doi.org/10.3389/fonc.2021.749881 |
work_keys_str_mv | AT shanying effectandmanagementofexcessweightinthecontextoffertilitysparingtreatmentsinpatientswithatypicalendometrialhyperplasiaandendometrialcancereightyearexperienceof227cases AT qinmeng effectandmanagementofexcessweightinthecontextoffertilitysparingtreatmentsinpatientswithatypicalendometrialhyperplasiaandendometrialcancereightyearexperienceof227cases AT yinjie effectandmanagementofexcessweightinthecontextoffertilitysparingtreatmentsinpatientswithatypicalendometrialhyperplasiaandendometrialcancereightyearexperienceof227cases AT caiyan effectandmanagementofexcessweightinthecontextoffertilitysparingtreatmentsinpatientswithatypicalendometrialhyperplasiaandendometrialcancereightyearexperienceof227cases AT liyan effectandmanagementofexcessweightinthecontextoffertilitysparingtreatmentsinpatientswithatypicalendometrialhyperplasiaandendometrialcancereightyearexperienceof227cases AT guyu effectandmanagementofexcessweightinthecontextoffertilitysparingtreatmentsinpatientswithatypicalendometrialhyperplasiaandendometrialcancereightyearexperienceof227cases AT wangwei effectandmanagementofexcessweightinthecontextoffertilitysparingtreatmentsinpatientswithatypicalendometrialhyperplasiaandendometrialcancereightyearexperienceof227cases AT wangyongxue effectandmanagementofexcessweightinthecontextoffertilitysparingtreatmentsinpatientswithatypicalendometrialhyperplasiaandendometrialcancereightyearexperienceof227cases AT chenjiayu effectandmanagementofexcessweightinthecontextoffertilitysparingtreatmentsinpatientswithatypicalendometrialhyperplasiaandendometrialcancereightyearexperienceof227cases AT jinying effectandmanagementofexcessweightinthecontextoffertilitysparingtreatmentsinpatientswithatypicalendometrialhyperplasiaandendometrialcancereightyearexperienceof227cases AT panlingya effectandmanagementofexcessweightinthecontextoffertilitysparingtreatmentsinpatientswithatypicalendometrialhyperplasiaandendometrialcancereightyearexperienceof227cases |