Mitotic Errors Promote Genomic Instability and Leukemia in a Novel Mouse Model of Fanconi Anemia

Fanconi anemia (FA) is a disease of genomic instability and cancer. In addition to DNA damage repair, FA pathway proteins are now known to be critical for maintaining faithful chromosome segregation during mitosis. While impaired DNA damage repair has been studied extensively in FA-associated carcin...

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Detalles Bibliográficos
Autores principales: Edwards, Donna M., Mitchell, Dana K., Abdul-Sater, Zahi, Chan, Ka-Kui, Sun, Zejin, Sheth, Aditya, He, Ying, Jiang, Li, Yuan, Jin, Sharma, Richa, Czader, Magdalena, Chin, Pei-Ju, Liu, Yie, de Cárcer, Guillermo, Nalepa, Grzegorz, Broxmeyer, Hal E., Clapp, D. Wade, Sierra Potchanant, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602820/
https://www.ncbi.nlm.nih.gov/pubmed/34804941
http://dx.doi.org/10.3389/fonc.2021.752933

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