HIVEP1 Is a Negative Regulator of NF-κB That Inhibits Systemic Inflammation in Sepsis

Our previous work identified human immunodeficiency virus type I enhancer binding protein 1 (HIVEP1) as a putative driver of LPS-induced NF-κB signaling in humans in vivo. While HIVEP1 is known to interact with NF-ĸB binding DNA motifs, its function in mammalian cells is unknown. We report increased...

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Detalles Bibliográficos
Autores principales: Matsumoto, Hisatake, Scicluna, Brendon P., Jim, Kin Ki, Falahi, Fahimeh, Qin, Wanhai, Gürkan, Berke, Malmström, Erik, Meijer, Mariska T., Butler, Joe M., Khan, Hina N., Takagi, Tsuyoshi, Ishii, Shunsuke, Schultz, Marcus J., van de Beek, Diederik, de Vos, Alex F., van ‘t Veer, Cornelis, van der Poll, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602905/
https://www.ncbi.nlm.nih.gov/pubmed/34804025
http://dx.doi.org/10.3389/fimmu.2021.744358

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