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Extracellular vesicles: General features and usefulness in diagnosis and therapeutic management of colorectal cancer

In the world, among all type of cancers, colorectal cancer (CRC) is the third most commonly diagnosed in males and the second in females. In most of cases, (RP1) patients’ prognosis limitation with malignant tumors can be attributed to delayed diagnosis of the disease. Identification of patients wit...

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Autores principales: Mammes, Aurelien, Pasquier, Jennifer, Mammes, Olivier, Conti, Marc, Douard, Richard, Loric, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8603448/
https://www.ncbi.nlm.nih.gov/pubmed/34853637
http://dx.doi.org/10.4251/wjgo.v13.i11.1561
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author Mammes, Aurelien
Pasquier, Jennifer
Mammes, Olivier
Conti, Marc
Douard, Richard
Loric, Sylvain
author_facet Mammes, Aurelien
Pasquier, Jennifer
Mammes, Olivier
Conti, Marc
Douard, Richard
Loric, Sylvain
author_sort Mammes, Aurelien
collection PubMed
description In the world, among all type of cancers, colorectal cancer (CRC) is the third most commonly diagnosed in males and the second in females. In most of cases, (RP1) patients’ prognosis limitation with malignant tumors can be attributed to delayed diagnosis of the disease. Identification of patients with early-stage disease leads to more effective therapeutic interventions. Therefore, new screening methods and further innovative treatment approaches are mandatory as they may lead to an increase in progression-free and overall survival rates. For the last decade, the interest in extracellular vesicles (EVs) research has exponentially increased as EVs generation appears to be a universal feature of every cell that is strongly involved in many mechanisms of cell-cell communication either in physiological or pathological situations. EVs can cargo biomolecules, such as lipids, proteins, nucleic acids and generate transmission signal through the intercellular transfer of their content. By this mechanism, tumor cells can recruit and modify the adjacent and systemic microenvironment to support further invasion and dissemination. This review intends to cover the most recent literature on the role of EVs production in colorectal normal and cancer tissues. Specific attention is paid to the use of EVs for early CRC diagnosis, follow-up, and prognosis as EVs have come into the spotlight of research as a high potential source of ‘liquid biopsies’. The use of EVs as new targets or nanovectors as drug delivery systems for CRC therapy is also summarized.
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spelling pubmed-86034482021-11-30 Extracellular vesicles: General features and usefulness in diagnosis and therapeutic management of colorectal cancer Mammes, Aurelien Pasquier, Jennifer Mammes, Olivier Conti, Marc Douard, Richard Loric, Sylvain World J Gastrointest Oncol Review In the world, among all type of cancers, colorectal cancer (CRC) is the third most commonly diagnosed in males and the second in females. In most of cases, (RP1) patients’ prognosis limitation with malignant tumors can be attributed to delayed diagnosis of the disease. Identification of patients with early-stage disease leads to more effective therapeutic interventions. Therefore, new screening methods and further innovative treatment approaches are mandatory as they may lead to an increase in progression-free and overall survival rates. For the last decade, the interest in extracellular vesicles (EVs) research has exponentially increased as EVs generation appears to be a universal feature of every cell that is strongly involved in many mechanisms of cell-cell communication either in physiological or pathological situations. EVs can cargo biomolecules, such as lipids, proteins, nucleic acids and generate transmission signal through the intercellular transfer of their content. By this mechanism, tumor cells can recruit and modify the adjacent and systemic microenvironment to support further invasion and dissemination. This review intends to cover the most recent literature on the role of EVs production in colorectal normal and cancer tissues. Specific attention is paid to the use of EVs for early CRC diagnosis, follow-up, and prognosis as EVs have come into the spotlight of research as a high potential source of ‘liquid biopsies’. The use of EVs as new targets or nanovectors as drug delivery systems for CRC therapy is also summarized. Baishideng Publishing Group Inc 2021-11-15 2021-11-15 /pmc/articles/PMC8603448/ /pubmed/34853637 http://dx.doi.org/10.4251/wjgo.v13.i11.1561 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Review
Mammes, Aurelien
Pasquier, Jennifer
Mammes, Olivier
Conti, Marc
Douard, Richard
Loric, Sylvain
Extracellular vesicles: General features and usefulness in diagnosis and therapeutic management of colorectal cancer
title Extracellular vesicles: General features and usefulness in diagnosis and therapeutic management of colorectal cancer
title_full Extracellular vesicles: General features and usefulness in diagnosis and therapeutic management of colorectal cancer
title_fullStr Extracellular vesicles: General features and usefulness in diagnosis and therapeutic management of colorectal cancer
title_full_unstemmed Extracellular vesicles: General features and usefulness in diagnosis and therapeutic management of colorectal cancer
title_short Extracellular vesicles: General features and usefulness in diagnosis and therapeutic management of colorectal cancer
title_sort extracellular vesicles: general features and usefulness in diagnosis and therapeutic management of colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8603448/
https://www.ncbi.nlm.nih.gov/pubmed/34853637
http://dx.doi.org/10.4251/wjgo.v13.i11.1561
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