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Prostaglandin E(2) sensitizes the cough reflex centrally via EP3 receptor-dependent activation of NaV 1.8 channels
BACKGROUND: Cough hypersensitivity is a major characteristic feature associated with several types of cough, including chronic cough, but its underlying mechanisms remain to be fully understood. Inflammatory mediators, such as prostaglandin E(2) (PGE(2)), have been implicated in both peripheral indu...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8603488/ https://www.ncbi.nlm.nih.gov/pubmed/34794450 http://dx.doi.org/10.1186/s12931-021-01889-4 |