Trend analysis of carbapenem-resistant Gram-negative bacteria and antimicrobial consumption in the post-COVID-19 era: an extra challenge for healthcare institutions

The incidence density trend of the carbapenem-resistant Gram-negative bacteria was analysed in device-associated infections and antimicrobial consumption in 99 critical care facilities in a low/middle-income country, between January 2019 and December 2020. Carbapenem-resistant Acinetobacter baumanni...

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Detalles Bibliográficos
Autores principales: de Carvalho Hessel Dias, V.M., Tuon, F., de Jesus Capelo, P., Telles, J.P., Fortaleza, C.M.C.B., Pellegrino Baena, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Healthcare Infection Society. Published by Elsevier Ltd. 2022
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8603865/
https://www.ncbi.nlm.nih.gov/pubmed/34808311
http://dx.doi.org/10.1016/j.jhin.2021.11.011
Descripción
Sumario:The incidence density trend of the carbapenem-resistant Gram-negative bacteria was analysed in device-associated infections and antimicrobial consumption in 99 critical care facilities in a low/middle-income country, between January 2019 and December 2020. Carbapenem-resistant Acinetobacter baumannii (CRAB) per 1000 patient-days increased in 2020 and this finding had a strong positive correlation with the incidence density of COVID-19 by the Spearman test. Polymyxin consumption also increased in 2020 but without significant correlation with CRAB or COVID-19 incidence density, presumably due to empirical and untargeted prescribing as a consequence of concern about CRAB infections. These findings are a warning to infection control programmes and antimicrobial stewardship.

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