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Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score

Background: Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19. Me...

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Autores principales: Abumayyaleh, Mohammad, Nuñez-Gil, Iván J., El-Battrawy, Ibrahim, Estrada, Vicente, Becerra-Muñoz, Víctor Manuel, Uribarri, Aitor, Fernández-Rozas, Inmaculada, Feltes, Gisela, Arroyo-Espliguero, Ramón, Trabattoni, Daniela, López Pais, Javier, Pepe, Martino, Romero, Rodolfo, Ortega-Armas, María Elizabeth, Bianco, Matteo, Astrua, Thamar Capel, D'Ascenzo, Fabrizio, Fabregat-Andres, Oscar, Ballester, Andrea, Marín, Francisco, Buonsenso, Danilo, Sanchez-Gimenez, Raul, Weiß, Christel, Fernandez Perez, Cristina, Fernández-Ortiz, Antonio, Macaya, Carlos, Akin, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8603931/
https://www.ncbi.nlm.nih.gov/pubmed/34805199
http://dx.doi.org/10.3389/fmed.2021.728102
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author Abumayyaleh, Mohammad
Nuñez-Gil, Iván J.
El-Battrawy, Ibrahim
Estrada, Vicente
Becerra-Muñoz, Víctor Manuel
Uribarri, Aitor
Fernández-Rozas, Inmaculada
Feltes, Gisela
Arroyo-Espliguero, Ramón
Trabattoni, Daniela
López Pais, Javier
Pepe, Martino
Romero, Rodolfo
Ortega-Armas, María Elizabeth
Bianco, Matteo
Astrua, Thamar Capel
D'Ascenzo, Fabrizio
Fabregat-Andres, Oscar
Ballester, Andrea
Marín, Francisco
Buonsenso, Danilo
Sanchez-Gimenez, Raul
Weiß, Christel
Fernandez Perez, Cristina
Fernández-Ortiz, Antonio
Macaya, Carlos
Akin, Ibrahim
author_facet Abumayyaleh, Mohammad
Nuñez-Gil, Iván J.
El-Battrawy, Ibrahim
Estrada, Vicente
Becerra-Muñoz, Víctor Manuel
Uribarri, Aitor
Fernández-Rozas, Inmaculada
Feltes, Gisela
Arroyo-Espliguero, Ramón
Trabattoni, Daniela
López Pais, Javier
Pepe, Martino
Romero, Rodolfo
Ortega-Armas, María Elizabeth
Bianco, Matteo
Astrua, Thamar Capel
D'Ascenzo, Fabrizio
Fabregat-Andres, Oscar
Ballester, Andrea
Marín, Francisco
Buonsenso, Danilo
Sanchez-Gimenez, Raul
Weiß, Christel
Fernandez Perez, Cristina
Fernández-Ortiz, Antonio
Macaya, Carlos
Akin, Ibrahim
author_sort Abumayyaleh, Mohammad
collection PubMed
description Background: Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19. Methods: We conducted a sub-analysis from the international Health Outcome Predictive Evaluation Registry for COVID-19 (HOPE-COVID-19-Registry, NCT04334291). Out of 5,837 patients with COVID-19, 624 patients were diagnosed with sepsis according to the Sepsis-3 International Consensus. Results: In multivariable analysis, the following risk factors were identified as independent predictors for developing sepsis: current smoking, tachypnoea (>22 breath per minute), hemoptysis, peripheral oxygen saturation (SpO(2)) <92%, blood pressure (BP) (systolic BP <90 mmHg and diastolic BP <60 mmHg), Glasgow Coma Scale (GCS) <15, elevated procalcitonin (PCT), elevated troponin I (TnI), and elevated creatinine >1.5 mg/dl. By assigning odds ratio (OR) weighted points to these variables, the following three risk categories were defined to develop sepsis during admission: low-risk group (probability of sepsis 3.1–11.8%); intermediate-risk group (24.8–53.8%); and high-risk-group (58.3–100%). A score of 1 was assigned to current smoking, tachypnoea, decreased SpO(2), decreased BP, decreased GCS, elevated PCT, TnI, and creatinine, whereas a score of 2 was assigned to hemoptysis. Conclusions: The HOPE Sepsis Score including nine parameters is useful in identifying high-risk COVID-19 patients to develop sepsis. Sepsis in COVID-19 is associated with a high mortality rate.
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spelling pubmed-86039312021-11-20 Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score Abumayyaleh, Mohammad Nuñez-Gil, Iván J. El-Battrawy, Ibrahim Estrada, Vicente Becerra-Muñoz, Víctor Manuel Uribarri, Aitor Fernández-Rozas, Inmaculada Feltes, Gisela Arroyo-Espliguero, Ramón Trabattoni, Daniela López Pais, Javier Pepe, Martino Romero, Rodolfo Ortega-Armas, María Elizabeth Bianco, Matteo Astrua, Thamar Capel D'Ascenzo, Fabrizio Fabregat-Andres, Oscar Ballester, Andrea Marín, Francisco Buonsenso, Danilo Sanchez-Gimenez, Raul Weiß, Christel Fernandez Perez, Cristina Fernández-Ortiz, Antonio Macaya, Carlos Akin, Ibrahim Front Med (Lausanne) Medicine Background: Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19. Methods: We conducted a sub-analysis from the international Health Outcome Predictive Evaluation Registry for COVID-19 (HOPE-COVID-19-Registry, NCT04334291). Out of 5,837 patients with COVID-19, 624 patients were diagnosed with sepsis according to the Sepsis-3 International Consensus. Results: In multivariable analysis, the following risk factors were identified as independent predictors for developing sepsis: current smoking, tachypnoea (>22 breath per minute), hemoptysis, peripheral oxygen saturation (SpO(2)) <92%, blood pressure (BP) (systolic BP <90 mmHg and diastolic BP <60 mmHg), Glasgow Coma Scale (GCS) <15, elevated procalcitonin (PCT), elevated troponin I (TnI), and elevated creatinine >1.5 mg/dl. By assigning odds ratio (OR) weighted points to these variables, the following three risk categories were defined to develop sepsis during admission: low-risk group (probability of sepsis 3.1–11.8%); intermediate-risk group (24.8–53.8%); and high-risk-group (58.3–100%). A score of 1 was assigned to current smoking, tachypnoea, decreased SpO(2), decreased BP, decreased GCS, elevated PCT, TnI, and creatinine, whereas a score of 2 was assigned to hemoptysis. Conclusions: The HOPE Sepsis Score including nine parameters is useful in identifying high-risk COVID-19 patients to develop sepsis. Sepsis in COVID-19 is associated with a high mortality rate. Frontiers Media S.A. 2021-10-14 /pmc/articles/PMC8603931/ /pubmed/34805199 http://dx.doi.org/10.3389/fmed.2021.728102 Text en Copyright © 2021 Abumayyaleh, Nuñez-Gil, El-Battrawy, Estrada, Becerra-Muñoz, Uribarri, Fernández-Rozas, Feltes, Arroyo-Espliguero, Trabattoni, López Pais, Pepe, Romero, Ortega-Armas, Bianco, Astrua, D'Ascenzo, Fabregat-Andres, Ballester, Marín, Buonsenso, Sanchez-Gimenez, Weiß, Fernandez Perez, Fernández-Ortiz, Macaya, Akin and HOPE COVID-19 Investigators. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Abumayyaleh, Mohammad
Nuñez-Gil, Iván J.
El-Battrawy, Ibrahim
Estrada, Vicente
Becerra-Muñoz, Víctor Manuel
Uribarri, Aitor
Fernández-Rozas, Inmaculada
Feltes, Gisela
Arroyo-Espliguero, Ramón
Trabattoni, Daniela
López Pais, Javier
Pepe, Martino
Romero, Rodolfo
Ortega-Armas, María Elizabeth
Bianco, Matteo
Astrua, Thamar Capel
D'Ascenzo, Fabrizio
Fabregat-Andres, Oscar
Ballester, Andrea
Marín, Francisco
Buonsenso, Danilo
Sanchez-Gimenez, Raul
Weiß, Christel
Fernandez Perez, Cristina
Fernández-Ortiz, Antonio
Macaya, Carlos
Akin, Ibrahim
Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score
title Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score
title_full Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score
title_fullStr Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score
title_full_unstemmed Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score
title_short Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score
title_sort sepsis of patients infected by sars-cov-2: real-world experience from the international hope-covid-19-registry and validation of hope sepsis score
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8603931/
https://www.ncbi.nlm.nih.gov/pubmed/34805199
http://dx.doi.org/10.3389/fmed.2021.728102
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