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Evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation
Pre‐clinical haematopoietic cell transplantation (HCT) studies in canines have proven to be invaluable for establishing HCT as a highly successful clinical option for the treatment of malignant and non‐malignant haematological diseases in humans. Additionally, studies in canines have shown that immu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604109/ https://www.ncbi.nlm.nih.gov/pubmed/34390541 http://dx.doi.org/10.1002/vms3.601 |
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author | Graves, Scott S. Storb, Rainer |
author_facet | Graves, Scott S. Storb, Rainer |
author_sort | Graves, Scott S. |
collection | PubMed |
description | Pre‐clinical haematopoietic cell transplantation (HCT) studies in canines have proven to be invaluable for establishing HCT as a highly successful clinical option for the treatment of malignant and non‐malignant haematological diseases in humans. Additionally, studies in canines have shown that immune tolerance, established following HCT, enabled transplantation of solid organs without the need of lifelong immunosuppression. This progress has been possible due to multiple biological similarities between dog and mankind. In this review, the hurdles that were overcome and the methods that were developed in the dog HCT model which made HCT clinically possible are examined. The results of these studies justify the question whether HCT can be used in the veterinary clinical practice for more wide‐spread successful treatment of canine haematologic and non‐haematologic disorders and whether it is prudent to do so. |
format | Online Article Text |
id | pubmed-8604109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86041092021-11-24 Evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation Graves, Scott S. Storb, Rainer Vet Med Sci Review Pre‐clinical haematopoietic cell transplantation (HCT) studies in canines have proven to be invaluable for establishing HCT as a highly successful clinical option for the treatment of malignant and non‐malignant haematological diseases in humans. Additionally, studies in canines have shown that immune tolerance, established following HCT, enabled transplantation of solid organs without the need of lifelong immunosuppression. This progress has been possible due to multiple biological similarities between dog and mankind. In this review, the hurdles that were overcome and the methods that were developed in the dog HCT model which made HCT clinically possible are examined. The results of these studies justify the question whether HCT can be used in the veterinary clinical practice for more wide‐spread successful treatment of canine haematologic and non‐haematologic disorders and whether it is prudent to do so. John Wiley and Sons Inc. 2021-08-14 /pmc/articles/PMC8604109/ /pubmed/34390541 http://dx.doi.org/10.1002/vms3.601 Text en © 2021 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Review Graves, Scott S. Storb, Rainer Evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation |
title | Evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation |
title_full | Evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation |
title_fullStr | Evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation |
title_full_unstemmed | Evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation |
title_short | Evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation |
title_sort | evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604109/ https://www.ncbi.nlm.nih.gov/pubmed/34390541 http://dx.doi.org/10.1002/vms3.601 |
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