Cargando…
Clinical efficacy and safety of antifungal drugs for the treatment of Candida parapsilosis infections: a systematic review and network meta-analysis
Antifungal drugs have already been established as an effective treatment option for Candida parapsilosis infections, but there is no universal consensus on the ideal target for clinical efficacy and safety of antifungal drugs for the treatment of C. parapsilosis infections. Few studies have directly...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Microbiology Society
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604171/ https://www.ncbi.nlm.nih.gov/pubmed/34633919 http://dx.doi.org/10.1099/jmm.0.001434 |
_version_ | 1784601900692275200 |
---|---|
author | Qin, Jielin Yang, Han Shan, Zhiming Jiang, Lingzhi Zhang, Qingxian |
author_facet | Qin, Jielin Yang, Han Shan, Zhiming Jiang, Lingzhi Zhang, Qingxian |
author_sort | Qin, Jielin |
collection | PubMed |
description | Antifungal drugs have already been established as an effective treatment option for Candida parapsilosis infections, but there is no universal consensus on the ideal target for clinical efficacy and safety of antifungal drugs for the treatment of C. parapsilosis infections. Few studies have directly compared the efficacies of antifungal drugs for the treatment of C. parapsilosis infections. We hypothesize that different antifungal drugs offer differing clinical efficacy and safety for the treatment of C. parapsilosis infections. We performed a comprehensive network meta-analysis on different strategies for C. parapsilosis infection treatment and compared the clinical efficacy and safety of antifungal drugs as interventions for C. parapsilosis infections. The Cochrane Database of Systematic Reviews, Medline, Embase, PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Technology of Chongqing VIP database, Wan Fang Data, and SinoMed databases were searched to identify appropriate randomized trials. Among the extracted C. parapsilosis cases, the survival and death rates with treatment of C. parapsilosis infection were compared among groups treated with different antifungal drugs. According to the evidence-network analysis, echinocandins were a better choice than other drugs for treating C. parapsilosis infections, and more importantly, caspofungin showed a more preferable effect for decreasing the risk of 30 day mortality. In conclusion, this study systematically evaluated the effectiveness and safety of antifungal drugs for the purpose of helping clinicians choose the most appropriate antifungal drugs. Future studies with larger samples are needed to evaluate the effects of patient factors on the clinical efficacy and safety of antifungal drugs for C. parapsilosis infections. |
format | Online Article Text |
id | pubmed-8604171 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Microbiology Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-86041712021-11-22 Clinical efficacy and safety of antifungal drugs for the treatment of Candida parapsilosis infections: a systematic review and network meta-analysis Qin, Jielin Yang, Han Shan, Zhiming Jiang, Lingzhi Zhang, Qingxian J Med Microbiol Prevention, Therapy and Therapeutics Antifungal drugs have already been established as an effective treatment option for Candida parapsilosis infections, but there is no universal consensus on the ideal target for clinical efficacy and safety of antifungal drugs for the treatment of C. parapsilosis infections. Few studies have directly compared the efficacies of antifungal drugs for the treatment of C. parapsilosis infections. We hypothesize that different antifungal drugs offer differing clinical efficacy and safety for the treatment of C. parapsilosis infections. We performed a comprehensive network meta-analysis on different strategies for C. parapsilosis infection treatment and compared the clinical efficacy and safety of antifungal drugs as interventions for C. parapsilosis infections. The Cochrane Database of Systematic Reviews, Medline, Embase, PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Technology of Chongqing VIP database, Wan Fang Data, and SinoMed databases were searched to identify appropriate randomized trials. Among the extracted C. parapsilosis cases, the survival and death rates with treatment of C. parapsilosis infection were compared among groups treated with different antifungal drugs. According to the evidence-network analysis, echinocandins were a better choice than other drugs for treating C. parapsilosis infections, and more importantly, caspofungin showed a more preferable effect for decreasing the risk of 30 day mortality. In conclusion, this study systematically evaluated the effectiveness and safety of antifungal drugs for the purpose of helping clinicians choose the most appropriate antifungal drugs. Future studies with larger samples are needed to evaluate the effects of patient factors on the clinical efficacy and safety of antifungal drugs for C. parapsilosis infections. Microbiology Society 2021-10-11 /pmc/articles/PMC8604171/ /pubmed/34633919 http://dx.doi.org/10.1099/jmm.0.001434 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License. |
spellingShingle | Prevention, Therapy and Therapeutics Qin, Jielin Yang, Han Shan, Zhiming Jiang, Lingzhi Zhang, Qingxian Clinical efficacy and safety of antifungal drugs for the treatment of Candida parapsilosis infections: a systematic review and network meta-analysis |
title | Clinical efficacy and safety of antifungal drugs for the treatment of Candida parapsilosis infections: a systematic review and network meta-analysis |
title_full | Clinical efficacy and safety of antifungal drugs for the treatment of Candida parapsilosis infections: a systematic review and network meta-analysis |
title_fullStr | Clinical efficacy and safety of antifungal drugs for the treatment of Candida parapsilosis infections: a systematic review and network meta-analysis |
title_full_unstemmed | Clinical efficacy and safety of antifungal drugs for the treatment of Candida parapsilosis infections: a systematic review and network meta-analysis |
title_short | Clinical efficacy and safety of antifungal drugs for the treatment of Candida parapsilosis infections: a systematic review and network meta-analysis |
title_sort | clinical efficacy and safety of antifungal drugs for the treatment of candida parapsilosis infections: a systematic review and network meta-analysis |
topic | Prevention, Therapy and Therapeutics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604171/ https://www.ncbi.nlm.nih.gov/pubmed/34633919 http://dx.doi.org/10.1099/jmm.0.001434 |
work_keys_str_mv | AT qinjielin clinicalefficacyandsafetyofantifungaldrugsforthetreatmentofcandidaparapsilosisinfectionsasystematicreviewandnetworkmetaanalysis AT yanghan clinicalefficacyandsafetyofantifungaldrugsforthetreatmentofcandidaparapsilosisinfectionsasystematicreviewandnetworkmetaanalysis AT shanzhiming clinicalefficacyandsafetyofantifungaldrugsforthetreatmentofcandidaparapsilosisinfectionsasystematicreviewandnetworkmetaanalysis AT jianglingzhi clinicalefficacyandsafetyofantifungaldrugsforthetreatmentofcandidaparapsilosisinfectionsasystematicreviewandnetworkmetaanalysis AT zhangqingxian clinicalefficacyandsafetyofantifungaldrugsforthetreatmentofcandidaparapsilosisinfectionsasystematicreviewandnetworkmetaanalysis |