Cargando…

Interferon responses to norovirus infections: current and future perspectives

Human noroviruses (HuNoVs) are increasingly becoming the main cause of transmissible gastroenteritis worldwide, with hundreds of thousands of deaths recorded annually. Yet, decades after their discovery, there is still no effective treatment or vaccine. Efforts aimed at developing vaccines or treatm...

Descripción completa

Detalles Bibliográficos
Autores principales: Jahun, Aminu S., Goodfellow, Ian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604187/
https://www.ncbi.nlm.nih.gov/pubmed/34698626
http://dx.doi.org/10.1099/jgv.0.001660
_version_ 1784601904788013056
author Jahun, Aminu S.
Goodfellow, Ian G.
author_facet Jahun, Aminu S.
Goodfellow, Ian G.
author_sort Jahun, Aminu S.
collection PubMed
description Human noroviruses (HuNoVs) are increasingly becoming the main cause of transmissible gastroenteritis worldwide, with hundreds of thousands of deaths recorded annually. Yet, decades after their discovery, there is still no effective treatment or vaccine. Efforts aimed at developing vaccines or treatment will benefit from a greater understanding of norovirus-host interactions, including the host response to infection. In this review, we provide a concise overview of the evidence establishing the significance of type I and type III interferon (IFN) responses in the restriction of noroviruses. We also critically examine our current understanding of the molecular mechanisms of IFN induction in norovirus-infected cells, and outline the diverse strategies deployed by noroviruses to supress and/or avoid host IFN responses. It is our hope that this review will facilitate further discussion and increase interest in this area.
format Online
Article
Text
id pubmed-8604187
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Microbiology Society
record_format MEDLINE/PubMed
spelling pubmed-86041872021-11-22 Interferon responses to norovirus infections: current and future perspectives Jahun, Aminu S. Goodfellow, Ian G. J Gen Virol Reviews Human noroviruses (HuNoVs) are increasingly becoming the main cause of transmissible gastroenteritis worldwide, with hundreds of thousands of deaths recorded annually. Yet, decades after their discovery, there is still no effective treatment or vaccine. Efforts aimed at developing vaccines or treatment will benefit from a greater understanding of norovirus-host interactions, including the host response to infection. In this review, we provide a concise overview of the evidence establishing the significance of type I and type III interferon (IFN) responses in the restriction of noroviruses. We also critically examine our current understanding of the molecular mechanisms of IFN induction in norovirus-infected cells, and outline the diverse strategies deployed by noroviruses to supress and/or avoid host IFN responses. It is our hope that this review will facilitate further discussion and increase interest in this area. Microbiology Society 2021-10-26 /pmc/articles/PMC8604187/ /pubmed/34698626 http://dx.doi.org/10.1099/jgv.0.001660 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
spellingShingle Reviews
Jahun, Aminu S.
Goodfellow, Ian G.
Interferon responses to norovirus infections: current and future perspectives
title Interferon responses to norovirus infections: current and future perspectives
title_full Interferon responses to norovirus infections: current and future perspectives
title_fullStr Interferon responses to norovirus infections: current and future perspectives
title_full_unstemmed Interferon responses to norovirus infections: current and future perspectives
title_short Interferon responses to norovirus infections: current and future perspectives
title_sort interferon responses to norovirus infections: current and future perspectives
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604187/
https://www.ncbi.nlm.nih.gov/pubmed/34698626
http://dx.doi.org/10.1099/jgv.0.001660
work_keys_str_mv AT jahunaminus interferonresponsestonorovirusinfectionscurrentandfutureperspectives
AT goodfellowiang interferonresponsestonorovirusinfectionscurrentandfutureperspectives