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Interferon responses to norovirus infections: current and future perspectives
Human noroviruses (HuNoVs) are increasingly becoming the main cause of transmissible gastroenteritis worldwide, with hundreds of thousands of deaths recorded annually. Yet, decades after their discovery, there is still no effective treatment or vaccine. Efforts aimed at developing vaccines or treatm...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Microbiology Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604187/ https://www.ncbi.nlm.nih.gov/pubmed/34698626 http://dx.doi.org/10.1099/jgv.0.001660 |
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author | Jahun, Aminu S. Goodfellow, Ian G. |
author_facet | Jahun, Aminu S. Goodfellow, Ian G. |
author_sort | Jahun, Aminu S. |
collection | PubMed |
description | Human noroviruses (HuNoVs) are increasingly becoming the main cause of transmissible gastroenteritis worldwide, with hundreds of thousands of deaths recorded annually. Yet, decades after their discovery, there is still no effective treatment or vaccine. Efforts aimed at developing vaccines or treatment will benefit from a greater understanding of norovirus-host interactions, including the host response to infection. In this review, we provide a concise overview of the evidence establishing the significance of type I and type III interferon (IFN) responses in the restriction of noroviruses. We also critically examine our current understanding of the molecular mechanisms of IFN induction in norovirus-infected cells, and outline the diverse strategies deployed by noroviruses to supress and/or avoid host IFN responses. It is our hope that this review will facilitate further discussion and increase interest in this area. |
format | Online Article Text |
id | pubmed-8604187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Microbiology Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-86041872021-11-22 Interferon responses to norovirus infections: current and future perspectives Jahun, Aminu S. Goodfellow, Ian G. J Gen Virol Reviews Human noroviruses (HuNoVs) are increasingly becoming the main cause of transmissible gastroenteritis worldwide, with hundreds of thousands of deaths recorded annually. Yet, decades after their discovery, there is still no effective treatment or vaccine. Efforts aimed at developing vaccines or treatment will benefit from a greater understanding of norovirus-host interactions, including the host response to infection. In this review, we provide a concise overview of the evidence establishing the significance of type I and type III interferon (IFN) responses in the restriction of noroviruses. We also critically examine our current understanding of the molecular mechanisms of IFN induction in norovirus-infected cells, and outline the diverse strategies deployed by noroviruses to supress and/or avoid host IFN responses. It is our hope that this review will facilitate further discussion and increase interest in this area. Microbiology Society 2021-10-26 /pmc/articles/PMC8604187/ /pubmed/34698626 http://dx.doi.org/10.1099/jgv.0.001660 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution. |
spellingShingle | Reviews Jahun, Aminu S. Goodfellow, Ian G. Interferon responses to norovirus infections: current and future perspectives |
title | Interferon responses to norovirus infections: current and future perspectives |
title_full | Interferon responses to norovirus infections: current and future perspectives |
title_fullStr | Interferon responses to norovirus infections: current and future perspectives |
title_full_unstemmed | Interferon responses to norovirus infections: current and future perspectives |
title_short | Interferon responses to norovirus infections: current and future perspectives |
title_sort | interferon responses to norovirus infections: current and future perspectives |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604187/ https://www.ncbi.nlm.nih.gov/pubmed/34698626 http://dx.doi.org/10.1099/jgv.0.001660 |
work_keys_str_mv | AT jahunaminus interferonresponsestonorovirusinfectionscurrentandfutureperspectives AT goodfellowiang interferonresponsestonorovirusinfectionscurrentandfutureperspectives |