Cargando…

Impact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease

INTRODUCTION: Breakdown of gut barrier integrity has been associated with inflammatory activation and is implicated in the etiology of several chronic medical conditions. Acute exercise is known to increase gut barrier permeability but the impact of chronic exercise is not clear. Most studies to dat...

Descripción completa

Detalles Bibliográficos
Autores principales: Feng, Vivian, Bawa, Kritleen K., Marzolini, Susan, Kiss, Alex, Oh, Paul, Herrmann, Nathan, Lanctôt, Krista L., Gallagher, Damien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604291/
https://www.ncbi.nlm.nih.gov/pubmed/34797867
http://dx.doi.org/10.1371/journal.pone.0260165
_version_ 1784601926030065664
author Feng, Vivian
Bawa, Kritleen K.
Marzolini, Susan
Kiss, Alex
Oh, Paul
Herrmann, Nathan
Lanctôt, Krista L.
Gallagher, Damien
author_facet Feng, Vivian
Bawa, Kritleen K.
Marzolini, Susan
Kiss, Alex
Oh, Paul
Herrmann, Nathan
Lanctôt, Krista L.
Gallagher, Damien
author_sort Feng, Vivian
collection PubMed
description INTRODUCTION: Breakdown of gut barrier integrity has been associated with inflammatory activation and is implicated in the etiology of several chronic medical conditions. Acute exercise is known to increase gut barrier permeability but the impact of chronic exercise is not clear. Most studies to date have examined how acute exercise impacts gut barrier integrity in healthy adults, while few studies have examined the impact of chronic exercise in older adults with comorbidities. We aim to investigate the impact of a 12-week program of aerobic and resistance training on biomarkers of gut barrier integrity in a sample of older adults with coronary artery disease. METHODS: Participants were adults with coronary artery disease undergoing a moderate-intensity 12-week cardiac rehabilitation exercise program. Fasting blood samples were taken at baseline and study termination. Serum levels of biomarkers of gut barrier integrity (zonulin and fatty acid-binding protein 2 (FABP2)) were measured by ELISA. Cardiorespiratory fitness was assessed by peak oxygen uptake (VO(2peak)) at study start & completion. Data analyses were performed using SPSS software version 24.0. RESULTS: Among study participants (n = 41, 70% male, age = 62.7± 9.35) we found a significant negative association between baseline FABP2 levels and baseline VO(2peak) in a multiple linear regression model adjusting for covariates (B = -0.3, p = 0.009). Over the course of the exercise program an increase in VO(2peak) (≥ 5 mL/kg/min) was independently associated with a relative decrease in FABP2 (B = -0.45, p = 0.018) after controlling for medical covariates. CONCLUSION: Our findings indicate that an increase in cardiorespiratory fitness during a 12-week exercise program resulted in a relative improvement in a biomarker of gut barrier integrity. This indicates a potential mechanism by which longer term exercise may improve gut barrier integrity.
format Online
Article
Text
id pubmed-8604291
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-86042912021-11-20 Impact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease Feng, Vivian Bawa, Kritleen K. Marzolini, Susan Kiss, Alex Oh, Paul Herrmann, Nathan Lanctôt, Krista L. Gallagher, Damien PLoS One Research Article INTRODUCTION: Breakdown of gut barrier integrity has been associated with inflammatory activation and is implicated in the etiology of several chronic medical conditions. Acute exercise is known to increase gut barrier permeability but the impact of chronic exercise is not clear. Most studies to date have examined how acute exercise impacts gut barrier integrity in healthy adults, while few studies have examined the impact of chronic exercise in older adults with comorbidities. We aim to investigate the impact of a 12-week program of aerobic and resistance training on biomarkers of gut barrier integrity in a sample of older adults with coronary artery disease. METHODS: Participants were adults with coronary artery disease undergoing a moderate-intensity 12-week cardiac rehabilitation exercise program. Fasting blood samples were taken at baseline and study termination. Serum levels of biomarkers of gut barrier integrity (zonulin and fatty acid-binding protein 2 (FABP2)) were measured by ELISA. Cardiorespiratory fitness was assessed by peak oxygen uptake (VO(2peak)) at study start & completion. Data analyses were performed using SPSS software version 24.0. RESULTS: Among study participants (n = 41, 70% male, age = 62.7± 9.35) we found a significant negative association between baseline FABP2 levels and baseline VO(2peak) in a multiple linear regression model adjusting for covariates (B = -0.3, p = 0.009). Over the course of the exercise program an increase in VO(2peak) (≥ 5 mL/kg/min) was independently associated with a relative decrease in FABP2 (B = -0.45, p = 0.018) after controlling for medical covariates. CONCLUSION: Our findings indicate that an increase in cardiorespiratory fitness during a 12-week exercise program resulted in a relative improvement in a biomarker of gut barrier integrity. This indicates a potential mechanism by which longer term exercise may improve gut barrier integrity. Public Library of Science 2021-11-19 /pmc/articles/PMC8604291/ /pubmed/34797867 http://dx.doi.org/10.1371/journal.pone.0260165 Text en © 2021 Feng et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Feng, Vivian
Bawa, Kritleen K.
Marzolini, Susan
Kiss, Alex
Oh, Paul
Herrmann, Nathan
Lanctôt, Krista L.
Gallagher, Damien
Impact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease
title Impact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease
title_full Impact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease
title_fullStr Impact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease
title_full_unstemmed Impact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease
title_short Impact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease
title_sort impact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604291/
https://www.ncbi.nlm.nih.gov/pubmed/34797867
http://dx.doi.org/10.1371/journal.pone.0260165
work_keys_str_mv AT fengvivian impactof12weekexerciseprogramonbiomarkersofgutbarrierintegrityinpatientswithcoronaryarterydisease
AT bawakritleenk impactof12weekexerciseprogramonbiomarkersofgutbarrierintegrityinpatientswithcoronaryarterydisease
AT marzolinisusan impactof12weekexerciseprogramonbiomarkersofgutbarrierintegrityinpatientswithcoronaryarterydisease
AT kissalex impactof12weekexerciseprogramonbiomarkersofgutbarrierintegrityinpatientswithcoronaryarterydisease
AT ohpaul impactof12weekexerciseprogramonbiomarkersofgutbarrierintegrityinpatientswithcoronaryarterydisease
AT herrmannnathan impactof12weekexerciseprogramonbiomarkersofgutbarrierintegrityinpatientswithcoronaryarterydisease
AT lanctotkristal impactof12weekexerciseprogramonbiomarkersofgutbarrierintegrityinpatientswithcoronaryarterydisease
AT gallagherdamien impactof12weekexerciseprogramonbiomarkersofgutbarrierintegrityinpatientswithcoronaryarterydisease