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Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia

INTRODUCTION: Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide, and several sociodemographic variables, comorbidities and care variables have been associated with complications and mortality. OBJECTIVE: To identify the factors associated with admission to intensive care...

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Autores principales: Machado-Alba, Jorge Enrique, Valladales-Restrepo, Luis Fernando, Machado-Duque, Manuel Enrique, Gaviria-Mendoza, Andrés, Sánchez-Ramírez, Nicolás, Usma-Valencia, Andrés Felipe, Rodríguez-Martínez, Esteban, Rengifo-Franco, Eliana, Forero-Supelano, Víctor Hugo, Gómez-Ramirez, Diego Mauricio, Sabogal-Ortiz, Alejandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604321/
https://www.ncbi.nlm.nih.gov/pubmed/34797857
http://dx.doi.org/10.1371/journal.pone.0260169
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author Machado-Alba, Jorge Enrique
Valladales-Restrepo, Luis Fernando
Machado-Duque, Manuel Enrique
Gaviria-Mendoza, Andrés
Sánchez-Ramírez, Nicolás
Usma-Valencia, Andrés Felipe
Rodríguez-Martínez, Esteban
Rengifo-Franco, Eliana
Forero-Supelano, Víctor Hugo
Gómez-Ramirez, Diego Mauricio
Sabogal-Ortiz, Alejandra
author_facet Machado-Alba, Jorge Enrique
Valladales-Restrepo, Luis Fernando
Machado-Duque, Manuel Enrique
Gaviria-Mendoza, Andrés
Sánchez-Ramírez, Nicolás
Usma-Valencia, Andrés Felipe
Rodríguez-Martínez, Esteban
Rengifo-Franco, Eliana
Forero-Supelano, Víctor Hugo
Gómez-Ramirez, Diego Mauricio
Sabogal-Ortiz, Alejandra
author_sort Machado-Alba, Jorge Enrique
collection PubMed
description INTRODUCTION: Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide, and several sociodemographic variables, comorbidities and care variables have been associated with complications and mortality. OBJECTIVE: To identify the factors associated with admission to intensive care units (ICUs) and mortality in patients with COVID-19 from 4 clinics in Colombia. METHODS: This was a follow-up study of a cohort of patients diagnosed with COVID-19 between March and August 2020. Sociodemographic, clinical (Charlson comorbidity index and NEWS 2 score) and pharmacological variables were identified. Multivariate analyses were performed to identify variables associated with the risk of admission to the ICU and death (p<0.05). RESULTS: A total of 780 patients were analyzed, with a median age of 57.0 years; 61.2% were male. On admission, 54.9% were classified as severely ill, 65.3% were diagnosed with acute respiratory distress syndrome, 32.4% were admitted to the ICU, and 26.0% died. The factors associated with a greater likelihood of ICU admission were severe pneumonia (OR: 9.86; 95%CI:5.99–16.23), each 1-point increase in the NEWS 2 score (OR:1.09; 95%CI:1.002–1.19), history of ischemic heart disease (OR:3.24; 95%CI:1.16–9.00), and chronic obstructive pulmonary disease (OR:2.07; 95%CI:1.09–3.90). The risk of dying increased in those older than 65 years (OR:3.08; 95%CI:1.66–5.71), in patients with acute renal failure (OR:6.96; 95%CI:4.41–11.78), admitted to the ICU (OR:6.31; 95%CI:3.63–10.95), and for each 1-point increase in the Charlson comorbidity index (OR:1.16; 95%CI:1.002–1.35). CONCLUSIONS: Factors related to increasing the probability of requiring ICU care or dying in patients with COVID-19 were identified, facilitating the development of anticipatory intervention measures that favor comprehensive care and improve patient prognosis.
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spelling pubmed-86043212021-11-20 Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia Machado-Alba, Jorge Enrique Valladales-Restrepo, Luis Fernando Machado-Duque, Manuel Enrique Gaviria-Mendoza, Andrés Sánchez-Ramírez, Nicolás Usma-Valencia, Andrés Felipe Rodríguez-Martínez, Esteban Rengifo-Franco, Eliana Forero-Supelano, Víctor Hugo Gómez-Ramirez, Diego Mauricio Sabogal-Ortiz, Alejandra PLoS One Research Article INTRODUCTION: Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide, and several sociodemographic variables, comorbidities and care variables have been associated with complications and mortality. OBJECTIVE: To identify the factors associated with admission to intensive care units (ICUs) and mortality in patients with COVID-19 from 4 clinics in Colombia. METHODS: This was a follow-up study of a cohort of patients diagnosed with COVID-19 between March and August 2020. Sociodemographic, clinical (Charlson comorbidity index and NEWS 2 score) and pharmacological variables were identified. Multivariate analyses were performed to identify variables associated with the risk of admission to the ICU and death (p<0.05). RESULTS: A total of 780 patients were analyzed, with a median age of 57.0 years; 61.2% were male. On admission, 54.9% were classified as severely ill, 65.3% were diagnosed with acute respiratory distress syndrome, 32.4% were admitted to the ICU, and 26.0% died. The factors associated with a greater likelihood of ICU admission were severe pneumonia (OR: 9.86; 95%CI:5.99–16.23), each 1-point increase in the NEWS 2 score (OR:1.09; 95%CI:1.002–1.19), history of ischemic heart disease (OR:3.24; 95%CI:1.16–9.00), and chronic obstructive pulmonary disease (OR:2.07; 95%CI:1.09–3.90). The risk of dying increased in those older than 65 years (OR:3.08; 95%CI:1.66–5.71), in patients with acute renal failure (OR:6.96; 95%CI:4.41–11.78), admitted to the ICU (OR:6.31; 95%CI:3.63–10.95), and for each 1-point increase in the Charlson comorbidity index (OR:1.16; 95%CI:1.002–1.35). CONCLUSIONS: Factors related to increasing the probability of requiring ICU care or dying in patients with COVID-19 were identified, facilitating the development of anticipatory intervention measures that favor comprehensive care and improve patient prognosis. Public Library of Science 2021-11-19 /pmc/articles/PMC8604321/ /pubmed/34797857 http://dx.doi.org/10.1371/journal.pone.0260169 Text en © 2021 Machado-Alba et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Machado-Alba, Jorge Enrique
Valladales-Restrepo, Luis Fernando
Machado-Duque, Manuel Enrique
Gaviria-Mendoza, Andrés
Sánchez-Ramírez, Nicolás
Usma-Valencia, Andrés Felipe
Rodríguez-Martínez, Esteban
Rengifo-Franco, Eliana
Forero-Supelano, Víctor Hugo
Gómez-Ramirez, Diego Mauricio
Sabogal-Ortiz, Alejandra
Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia
title Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia
title_full Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia
title_fullStr Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia
title_full_unstemmed Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia
title_short Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia
title_sort factors associated with admission to the intensive care unit and mortality in patients with covid-19, colombia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604321/
https://www.ncbi.nlm.nih.gov/pubmed/34797857
http://dx.doi.org/10.1371/journal.pone.0260169
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