The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma

While comprehensive molecular profiling of histone H3.3 mutant pediatric high-grade glioma has revealed extensive dysregulation of the chromatin landscape, the exact mechanisms driving tumor formation remain poorly understood. Since H3.3 mutant gliomas also exhibit high levels of copy number alterat...

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Detalles Bibliográficos
Autores principales: Bočkaj, Irena, Martini, Tosca E. I., de Camargo Magalhães, Eduardo S., Bakker, Petra L., Meeuwsen-de Boer, Tiny G. J., Armandari, Inna, Meuleman, Saskia L., Mondria, Marin T., Stok, Colin, Kok, Yannick P., Bakker, Bjorn, Wardenaar, René, Seiler, Jonas, Broekhuis, Mathilde J. C., van den Bos, Hilda, Spierings, Diana C. J., Ringnalda, Femke C. A., Clevers, Hans, Schüller, Ulrich, van Vugt, Marcel A. T. M., Foijer, Floris, Bruggeman, Sophia W. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604337/
https://www.ncbi.nlm.nih.gov/pubmed/34752469
http://dx.doi.org/10.1371/journal.pgen.1009868

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