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O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans

Neurodevelopmental disorders such as epilepsy and autism have been linked to an imbalance of excitation and inhibition (E/I) in the central nervous system. The simplicity and tractability of C. elegans allows our electroconvulsive seizure (ES) assay to be used as a behavioral readout of the locomoto...

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Detalles Bibliográficos
Autores principales:	Suthakaran, Nirthieca, Wiggins, Jonathan, Giles, Andrew, Opperman, Karla J., Grill, Brock, Dawson-Scully, Ken
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604358/ https://www.ncbi.nlm.nih.gov/pubmed/34797853 http://dx.doi.org/10.1371/journal.pone.0260072

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