Deubiquitination of proteasome subunits by OTULIN regulates type I IFN production

OTULIN is a linear deubiquitinase that negatively regulates the nuclear factor κB (NF-κB) signaling pathway. Patients with OTULIN deficiency, termed as otulipenia or OTULIN-related autoinflammatory syndrome, present with early onset severe systemic inflammation due to increased NF-κB activation. We...

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Detalles Bibliográficos
Autores principales: Tao, Panfeng, Wang, Shihao, Ozen, Seza, Lee, Pui Y., Zhang, Jiahui, Wang, Jun, Han, Huan, Yang, Zhaohui, Fang, Ran, Tsai, Wanxia Li, Yang, Huanming, Sag, Erdal, Topaloglu, Rezan, Aksentijevich, Ivona, Yu, Xiaomin, Zhou, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604410/
https://www.ncbi.nlm.nih.gov/pubmed/34797715
http://dx.doi.org/10.1126/sciadv.abi6794

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