5′ Half of specific tRNAs feeds back to promote corresponding tRNA gene transcription in vertebrate embryos

5′tRFls are small transfer RNA (tRNA) fragments derived from 5′ half of mature tRNAs. However, it is unknown whether 5′tRFls could feed back to regulate tRNA biogenesis. Here, we show that 5′tRFl(Gly/GCC) and 5′tRFl(Glu/CTC) function to promote transcription of corresponding tRNA genes and are essen...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Luxi, Xu, Wei, Liu, Kunpeng, Jiang, Zheng, Han, Yang, Jin, Hongbin, Zhang, Lin, Shen, Weimin, Jia, Shunji, Sun, Qianwen, Meng, Anming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604414/
https://www.ncbi.nlm.nih.gov/pubmed/34797706
http://dx.doi.org/10.1126/sciadv.abh0494

Ejemplares similares

Ejemplares similares