Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression

Infection by (re-)emerging RNA arboviruses including Chikungunya virus (CHIKV) and Mayaro virus primarily cause acute febrile disease and transient polyarthralgia. However, in a significant subset of infected individuals, debilitating arthralgia persists for weeks over months up to years. The underl...

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Detalles Bibliográficos
Autores principales: Pott, Fabian, Postmus, Dylan, Brown, Richard J. P., Wyler, Emanuel, Neumann, Elena, Landthaler, Markus, Goffinet, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604527/
https://www.ncbi.nlm.nih.gov/pubmed/34723780
http://dx.doi.org/10.1080/22221751.2021.2000891

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