Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapy

CRISPR/Cas9-based gene editing has emerged as a powerful biotechnological tool, that relies on Cas9 protein and single guided RNA (sgRNA) to edit target DNA. However, the lack of safe and efficient delivery carrier is one of the crucial factors restricting its clinical transformation. Here, we repor...

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Detalles Bibliográficos
Autores principales: Li, Chunhui, Yang, Tongren, Weng, Yuhua, Zhang, Mengjie, Zhao, Deyao, Guo, Shuai, Hu, Bo, Shao, Wanxuan, Wang, Xiaoxia, Hussain, Abid, Liang, Xing-Jie, Huang, Yuanyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604671/
https://www.ncbi.nlm.nih.gov/pubmed/34853819
http://dx.doi.org/10.1016/j.bioactmat.2021.05.051

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