Identification of SUMO Targets Associated With the Pluripotent State in Human Stem Cells

To investigate the role of SUMO modification in the maintenance of pluripotent stem cells, we used ML792, a potent and selective inhibitor of SUMO Activating Enzyme. Treatment of human induced pluripotent stem cells with ML792 resulted in the loss of key pluripotency markers. To identify putative ef...

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Detalles Bibliográficos
Autores principales: Mojsa, Barbara, Tatham, Michael H., Davidson, Lindsay, Liczmanska, Magda, Branigan, Emma, Hay, Ronald T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604812/
https://www.ncbi.nlm.nih.gov/pubmed/34673284
http://dx.doi.org/10.1016/j.mcpro.2021.100164

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