Development of PBPK model for intra-articular injection in human: methotrexate solution and rheumatoid arthritis case study

A physiologically based model describing the dissolution, diffusion, and transfer of drug from the intra-articular (IA) space to the plasma, was developed for GastroPlus® v9.8. The model is subdivided into compartments representing the synovial fluid, synovium, and cartilage. The synovium is broken...

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Detalles Bibliográficos
Autores principales: Le Merdy, Maxime, Mullin, Jim, Lukacova, Viera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604827/
https://www.ncbi.nlm.nih.gov/pubmed/34569001
http://dx.doi.org/10.1007/s10928-021-09781-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604827/
https://www.ncbi.nlm.nih.gov/pubmed/34569001
http://dx.doi.org/10.1007/s10928-021-09781-w

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