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The genetic architecture of DNA replication timing in human pluripotent stem cells

DNA replication follows a strict spatiotemporal program that intersects with chromatin structure but has a poorly understood genetic basis. To systematically identify genetic regulators of replication timing, we exploited inter-individual variation in human pluripotent stem cells from 349 individual...

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Detalles Bibliográficos
Autores principales:	Ding, Qiliang, Edwards, Matthew M., Wang, Ning, Zhu, Xiang, Bracci, Alexa N., Hulke, Michelle L., Hu, Ya, Tong, Yao, Hsiao, Joyce, Charvet, Christine J., Ghosh, Sulagna, Handsaker, Robert E., Eggan, Kevin, Merkle, Florian T., Gerhardt, Jeannine, Egli, Dieter, Clark, Andrew G., Koren, Amnon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604924/ https://www.ncbi.nlm.nih.gov/pubmed/34799581 http://dx.doi.org/10.1038/s41467-021-27115-9

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