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The autophagy protein ATG9A enables lipid mobilization from lipid droplets

The multispanning membrane protein ATG9A is a scramblase that flips phospholipids between the two membrane leaflets, thus contributing to the expansion of the phagophore membrane in the early stages of autophagy. Herein, we show that depletion of ATG9A does not only inhibit autophagy but also increa...

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Detalles Bibliográficos
Autores principales: Mailler, Elodie, Guardia, Carlos M., Bai, Xiaofei, Jarnik, Michal, Williamson, Chad D., Li, Yan, Maio, Nunziata, Golden, Andy, Bonifacino, Juan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605025/
https://www.ncbi.nlm.nih.gov/pubmed/34799570
http://dx.doi.org/10.1038/s41467-021-26999-x