Cargando…

The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition

The p38 mitogen-activated protein kinases (p38 MAPK) is a 38kD polypeptide recognized as the target for many potential anti-inflammatory agents. Accumulating evidence indicates that p38 MAPK could perform many roles in human disease pathophysiology. Therefore, great therapeutic benefits can be attai...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arafa, El-Shaimaa A., Refaey, Mohamed S., Abd El-Ghafar, Omnia A.M., Hassanein, Emad H.M., Sayed, Ahmed M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605069/ https://www.ncbi.nlm.nih.gov/pubmed/34825082 http://dx.doi.org/10.1016/j.heliyon.2021.e08354

Ejemplares similares

Camel Milk Mitigates Cyclosporine-Induced Renal Damage in Rats: Targeting p38/ERK/JNK MAPKs, NF-κB, and Matrix Metalloproteinases
por: Arab, Hany H., et al.
Publicado: (2021)

p38 MAPK inhibition: A promising therapeutic approach for COVID-19
por: Grimes, Joseph M., et al.
Publicado: (2020)

Edaravone and Acetovanillone Upregulate Nrf2 and PI3K/Akt/mTOR Signaling and Prevent Cyclophosphamide Cardiotoxicity in Rats
por: Hassanein, Emad H M, et al.
Publicado: (2020)

Candesartan Attenuates Cisplatin-Induced Lung Injury by Modulating Oxidative Stress, Inflammation, and TLR-4/NF-κB, JAK1/STAT3, and Nrf2/HO-1 Signaling
por: Atwa, Ahmed M., et al.
Publicado: (2022)

Tangeretin Alleviates Cisplatin-Induced Acute Hepatic Injury in Rats: Targeting MAPKs and Apoptosis
por: Omar, Hany A., et al.
Publicado: (2016)

Azithromycin Mitigates Cisplatin-Induced Lung Oxidative Stress, Inflammation and Necroptosis by Upregulating SIRT1, PPARγ, and Nrf2/HO-1 Signaling
por: Hassanein, Emad H. M., et al.
Publicado: (2022)

Microbiota and epigenetics: promising therapeutic approaches?
por: El-Sayed, Amr, et al.
Publicado: (2021)

miRNAs and Stem Cells as Promising Diagnostic and Therapeutic Targets for Alzheimer’s Disease
por: Elzayat, Emad M., et al.
Publicado: (2023)

Formulation and characterization of chlorhexidine HCl nanoemulsion as a promising antibacterial root canal irrigant: in-vitro and ex-vivo studies
por: Abdelmonem, Rehab, et al.
Publicado: (2019)

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway
por: Hassanein, Emad H. M., et al.
Publicado: (2020)

Spanlastic-laden in situ gel as a promising approach for ocular delivery of Levofloxacin: In-vitro characterization, microbiological assessment, corneal permeability and in-vivo study
por: Agha, Omnia Ahmed, et al.
Publicado: (2023)

Removal of Hazardous Contaminants from Water by Natural and Zwitterionic Surfactant-modified Clay
por: Abdel Ghafar, Hany H., et al.
Publicado: (2020)

Therapeutic Implications of a Polymethoxylated Flavone, Tangeretin, in the Management of Cancer via Modulation of Different Molecular Pathways
por: Arafa, El-Shaimaa A., et al.
Publicado: (2021)

Marine Brominated Tyrosine Alkaloids as Promising Inhibitors of SARS-CoV-2
por: El-Demerdash, Amr, et al.
Publicado: (2021)

Is p38 MAPK Associated to Drugs of Abuse-Induced Abnormal Behaviors?
por: El Rawas, Rana, et al.
Publicado: (2020)

Editorial: Safety of Polyphenolic Compounds and Their Role in Cardiovascular Diseases
por: Ahmed, Lamiaa A., et al.
Publicado: (2022)

Therapeutic interventions target the NLRP3 inflammasome in ulcerative colitis: Comprehensive study
por: Ali, Fares E.M, et al.
Publicado: (2023)

Efficacy of favipiravir in COVID-19 treatment: a multi-center randomized study
por: Dabbous, Hany M., et al.
Publicado: (2021)

Retraction Note to: Efficacy of favipiravir in COVID‑19 treatment: a multi‑center randomized study
por: Dabbous, Hany M., et al.
Publicado: (2021)

Impact of gut microbiota composition on black cutworm, Agrotis ipsilon (hufnagel) metabolic indices and pesticide degradation
por: ElKraly, Omnia Abdullah, et al.
Publicado: (2023)

Nano Methotrexate versus Methotrexate in Targeting Rheumatoid Arthritis
por: Salem, Heba F., et al.
Publicado: (2022)

Identification of p38 MAPK as a novel therapeutic target for Friedreich’s ataxia
por: Cotticelli, M. Grazia, et al.
Publicado: (2018)

Brain-targeted delivery of Valsartan using solid lipid nanoparticles labeled with Rhodamine B; a promising technique for mitigating the negative effects of stroke
por: Sabry, Shereen A., et al.
Publicado: (2023)

p38MAPK Signaling Pathway in Osteoarthritis: Pathological and Therapeutic Aspects
por: Li, Zongchao, et al.
Publicado: (2022)

Falls and associated risk factors in a sample of old age population in Egyptian community
por: El Sayed, Abd El Hamied Ibrahim, et al.
Publicado: (2023)

Ginsenoside Rb1 prevents homocysteine-induced EPC dysfunction via VEGF/p38MAPK and SDF-1/CXCR4 activation
por: Lan, Tao-Hua, et al.
Publicado: (2017)

Investigating the structure-activity relationship of marine polycyclic batzelladine alkaloids as promising inhibitors for SARS-CoV-2 main protease (M(pro))
por: Elgohary, Alaa M., et al.
Publicado: (2022)

p38 MAPK in MDS
por: Gañán‐Gómez, Irene, et al.
Publicado: (2015)

Regulation of Sirtuin-3 and ERK1/2/p38MAPK by the combination Ga nanoparticles/γ-radiation low dosage: an effective approach for treatment of hepatocellular carcinoma
por: Abdalla, Mohga S., et al.
Publicado: (2022)

Exploiting the exceptional biosynthetic potency of the endophytic Aspergillus terreus in enhancing production of Co(3)O(4), CuO, Fe(3)O(4), NiO, and ZnO nanoparticles using bioprocess optimization and gamma irradiation
por: El-Sayed, El-Sayed R., et al.
Publicado: (2022)

Bifunctional role of some biogenic nanoparticles in controlling wilt disease and promoting growth of common bean
por: El-Sayed, El-Sayed R., et al.
Publicado: (2023)

Recurrence after correction of acquired ankle equinus deformity in children using Ilizarov technique
por: Emara, Khaled M., et al.
Publicado: (2008)

Investigating the hepatoprotective potentiality of marine-derived steroids as promising inhibitors of liver fibrosis
por: Tammam, Mohamed A., et al.
Publicado: (2023)

Mitigation of Rheumatic Arthritis in a Rat Model via Transdermal Delivery of Dapoxetine HCl Amalgamated as a Nanoplatform: In vitro and in vivo Assessment
por: Salem, Heba Farouk, et al.
Publicado: (2020)

p38 MAPK in cardioprotection – are we there yet?
por: Martin, E D, et al.
Publicado: (2015)

Ginsenoside Rg1 Mitigates Porcine Intestinal Tight Junction Disruptions Induced by LPS through the p38 MAPK/NLRP3 Inflammasome Pathway
por: Kang, Jian, et al.
Publicado: (2022)

Mechanical vestibular stimulation versus traditional balance exercises in children with Down syndrome
por: Nahla, Ibrahim M, et al.
Publicado: (2022)

The p38 MAPK Signaling Activation in Colorectal Cancer upon Therapeutic Treatments
por: Pranteda, Angelina, et al.
Publicado: (2020)

p38 MAPKs — roles in skeletal muscle physiology, disease mechanisms, and as potential therapeutic targets
por: Brennan, Christopher M., et al.
Publicado: (2021)

A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer
por: Braicu, Cornelia, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_47g42rspc4n9re5t2tqa8u3rle