Efficacy and safety of a third-generation oncolytic herpes virus G47Δ in models of human esophageal carcinoma

Treatment options are limited for esophageal carcinoma (EC). G47Δ, a triple-mutated, conditionally replicating herpes simplex virus type 1 (HSV-1), exhibits enhanced killing of tumor cells with high safety features. Here, we studied the efficacy of G47Δ using preclinical models of human EC. In vitro...

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Detalles Bibliográficos
Autores principales: Yajima, Shoh, Sugawara, Kotaro, Iwai, Miwako, Tanaka, Minoru, Seto, Yasuyuki, Todo, Tomoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605086/
https://www.ncbi.nlm.nih.gov/pubmed/34853811
http://dx.doi.org/10.1016/j.omto.2021.10.012

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