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CircRNAs: a family number of miRNA regulatory transcriptome in laryngeal carcinoma
Laryngeal carcinoma (LC) is a common head and neck cancer, which is the result of mutational changes due to gene dysregulation and etiological factors such as tobacco and smoking. A large number of patients received a poor prognosis due to diagnosis at an advanced stage. This highlights the need for...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605118/ https://www.ncbi.nlm.nih.gov/pubmed/34617636 http://dx.doi.org/10.1002/jcla.24038 |
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author | Miao, Limin Feng, Guanying Yuan, Hua |
author_facet | Miao, Limin Feng, Guanying Yuan, Hua |
author_sort | Miao, Limin |
collection | PubMed |
description | Laryngeal carcinoma (LC) is a common head and neck cancer, which is the result of mutational changes due to gene dysregulation and etiological factors such as tobacco and smoking. A large number of patients received a poor prognosis due to diagnosis at an advanced stage. This highlights the need for definitive, early, and efficient diagnoses. With rapid development of high‐throughput sequencing, circular RNA (circRNA) has been reported to play a pivotal role in cancer. CircRNA functions as a microRNA (miRNA) sponge in the regulation of mRNA expression, forming circRNA‐miRNA regulatory axis. In this review, we described the axis in LC. The result indicated that CDR1as, hsa_circ_0042823, hsa_circ_0023028, circPARD3, hsa_circ_103862, hsa_circ_0000218, circMYLK, circCORO1C, hsa_circ_100290, circ‐CCND1, hsa_circ_0057481, circFLAN, and circRASSF2 expressed higher in LC, whereas, hsa_circ_0036722 and hsa_circ_0042666 expressed lower. The circRNAs regulated the target genes by sponging miRNAs and contributed to the pathogenesis of LC. |
format | Online Article Text |
id | pubmed-8605118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86051182021-11-24 CircRNAs: a family number of miRNA regulatory transcriptome in laryngeal carcinoma Miao, Limin Feng, Guanying Yuan, Hua J Clin Lab Anal Review Article Laryngeal carcinoma (LC) is a common head and neck cancer, which is the result of mutational changes due to gene dysregulation and etiological factors such as tobacco and smoking. A large number of patients received a poor prognosis due to diagnosis at an advanced stage. This highlights the need for definitive, early, and efficient diagnoses. With rapid development of high‐throughput sequencing, circular RNA (circRNA) has been reported to play a pivotal role in cancer. CircRNA functions as a microRNA (miRNA) sponge in the regulation of mRNA expression, forming circRNA‐miRNA regulatory axis. In this review, we described the axis in LC. The result indicated that CDR1as, hsa_circ_0042823, hsa_circ_0023028, circPARD3, hsa_circ_103862, hsa_circ_0000218, circMYLK, circCORO1C, hsa_circ_100290, circ‐CCND1, hsa_circ_0057481, circFLAN, and circRASSF2 expressed higher in LC, whereas, hsa_circ_0036722 and hsa_circ_0042666 expressed lower. The circRNAs regulated the target genes by sponging miRNAs and contributed to the pathogenesis of LC. John Wiley and Sons Inc. 2021-10-07 /pmc/articles/PMC8605118/ /pubmed/34617636 http://dx.doi.org/10.1002/jcla.24038 Text en © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Review Article Miao, Limin Feng, Guanying Yuan, Hua CircRNAs: a family number of miRNA regulatory transcriptome in laryngeal carcinoma |
title | CircRNAs: a family number of miRNA regulatory transcriptome in laryngeal carcinoma |
title_full | CircRNAs: a family number of miRNA regulatory transcriptome in laryngeal carcinoma |
title_fullStr | CircRNAs: a family number of miRNA regulatory transcriptome in laryngeal carcinoma |
title_full_unstemmed | CircRNAs: a family number of miRNA regulatory transcriptome in laryngeal carcinoma |
title_short | CircRNAs: a family number of miRNA regulatory transcriptome in laryngeal carcinoma |
title_sort | circrnas: a family number of mirna regulatory transcriptome in laryngeal carcinoma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605118/ https://www.ncbi.nlm.nih.gov/pubmed/34617636 http://dx.doi.org/10.1002/jcla.24038 |
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