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CXCL8, CXCL9, and CXCL10 serum levels increase in syphilitic patients with seroresistance

BACKGROUND: Recently, the rise of syphilitic seroresistance brings great confusion to the clinical diagnosis and treatment of syphilis, and no clear diagnostic marker has been found to distinguish syphilitic seroresistance from other progression of syphilis. This study evaluated the serum chemokines...

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Autores principales: Dong, Xiaoyan, Zhang, Junwu, Yang, Fangfang, Liu, Jinlin, Peng, Yumeng, Ge, Yumei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605156/
https://www.ncbi.nlm.nih.gov/pubmed/34555221
http://dx.doi.org/10.1002/jcla.24016
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author Dong, Xiaoyan
Zhang, Junwu
Yang, Fangfang
Liu, Jinlin
Peng, Yumeng
Ge, Yumei
author_facet Dong, Xiaoyan
Zhang, Junwu
Yang, Fangfang
Liu, Jinlin
Peng, Yumeng
Ge, Yumei
author_sort Dong, Xiaoyan
collection PubMed
description BACKGROUND: Recently, the rise of syphilitic seroresistance brings great confusion to the clinical diagnosis and treatment of syphilis, and no clear diagnostic marker has been found to distinguish syphilitic seroresistance from other progression of syphilis. This study evaluated the serum chemokines levels of CCL2, CXCL8, CXCL9, and CXCL10 and its correlation with blood routine, coagulation, and biochemical indexes in seroresistant syphilitic patients. METHOD: Serum levels of chemokines were quantitatively determined by Flow Cytometric Bead Array (CBA). The results expressed in pg/ml. Clinical parameters were detected and analyzed according to the clinical laboratory standards. A correlation analysis was subsequently performed. RESULTS: The seroresistant syphilitic patients increased significantly serum chemokines levels of CXCL8 (***p < 0.001), CXCL9 (***p < 0.001), and CXCL10 (**p < 0.01) when compared to noninfected individuals, but the CCL2 was not statistically significant, and serum CXCL8 shows a strong association with platelets (r = 0.51, **p = 0.004) and serum CXCL10 was significantly positively related to INR levels (r = 0.49, **p = 0.007). CONCLUSION: Increasing serum abnormalities in CXCL8, CXCL9, and CXCL10 level combining with platelets of peripheral blood and plasmatic INR in syphilis patients may be helpful for the diagnosis of serofast state.
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spelling pubmed-86051562021-11-24 CXCL8, CXCL9, and CXCL10 serum levels increase in syphilitic patients with seroresistance Dong, Xiaoyan Zhang, Junwu Yang, Fangfang Liu, Jinlin Peng, Yumeng Ge, Yumei J Clin Lab Anal Research Articles BACKGROUND: Recently, the rise of syphilitic seroresistance brings great confusion to the clinical diagnosis and treatment of syphilis, and no clear diagnostic marker has been found to distinguish syphilitic seroresistance from other progression of syphilis. This study evaluated the serum chemokines levels of CCL2, CXCL8, CXCL9, and CXCL10 and its correlation with blood routine, coagulation, and biochemical indexes in seroresistant syphilitic patients. METHOD: Serum levels of chemokines were quantitatively determined by Flow Cytometric Bead Array (CBA). The results expressed in pg/ml. Clinical parameters were detected and analyzed according to the clinical laboratory standards. A correlation analysis was subsequently performed. RESULTS: The seroresistant syphilitic patients increased significantly serum chemokines levels of CXCL8 (***p < 0.001), CXCL9 (***p < 0.001), and CXCL10 (**p < 0.01) when compared to noninfected individuals, but the CCL2 was not statistically significant, and serum CXCL8 shows a strong association with platelets (r = 0.51, **p = 0.004) and serum CXCL10 was significantly positively related to INR levels (r = 0.49, **p = 0.007). CONCLUSION: Increasing serum abnormalities in CXCL8, CXCL9, and CXCL10 level combining with platelets of peripheral blood and plasmatic INR in syphilis patients may be helpful for the diagnosis of serofast state. John Wiley and Sons Inc. 2021-09-23 /pmc/articles/PMC8605156/ /pubmed/34555221 http://dx.doi.org/10.1002/jcla.24016 Text en © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Dong, Xiaoyan
Zhang, Junwu
Yang, Fangfang
Liu, Jinlin
Peng, Yumeng
Ge, Yumei
CXCL8, CXCL9, and CXCL10 serum levels increase in syphilitic patients with seroresistance
title CXCL8, CXCL9, and CXCL10 serum levels increase in syphilitic patients with seroresistance
title_full CXCL8, CXCL9, and CXCL10 serum levels increase in syphilitic patients with seroresistance
title_fullStr CXCL8, CXCL9, and CXCL10 serum levels increase in syphilitic patients with seroresistance
title_full_unstemmed CXCL8, CXCL9, and CXCL10 serum levels increase in syphilitic patients with seroresistance
title_short CXCL8, CXCL9, and CXCL10 serum levels increase in syphilitic patients with seroresistance
title_sort cxcl8, cxcl9, and cxcl10 serum levels increase in syphilitic patients with seroresistance
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605156/
https://www.ncbi.nlm.nih.gov/pubmed/34555221
http://dx.doi.org/10.1002/jcla.24016
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