Missense mutation in selenocysteine synthase causes cardio-respiratory failure and perinatal death in mice which can be compensated by selenium-independent GPX4

Selenoproteins are a small family of proteins containing the trace element selenium in form of the rare amino acid selenocysteine (Sec), which is decoded by the UGA codon. In humans, a number of pathogenic variants in genes encoding distinct selenoproteins or selenoprotein biosynthesis factors have...

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Detalles Bibliográficos
Autores principales: Fradejas-Villar, Noelia, Zhao, Wenchao, Reuter, Uschi, Doengi, Michael, Ingold, Irina, Bohleber, Simon, Conrad, Marcus, Schweizer, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605217/
https://www.ncbi.nlm.nih.gov/pubmed/34794077
http://dx.doi.org/10.1016/j.redox.2021.102188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605217/
https://www.ncbi.nlm.nih.gov/pubmed/34794077
http://dx.doi.org/10.1016/j.redox.2021.102188

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