Mbd2 deficiency alleviates retinal cell apoptosisvia the miR-345-5p/Atf1 axis in high glucoseinjury and streptozotocin-induced diabetic mice

DNA methylation is considered to play an important role in the development of diabetic retinopathy. Here, our goal was to investigate the precise role of methyl-CpG binding domain protein 2 (Mbd2) in the apoptosis of retinal ganglion cells (RGCs) in the early diabetic retina. Mbd2 was significantly...

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Detalles Bibliográficos
Autores principales: Ge, Yanni, Zhang, Ran, Feng, Yuqing, Lu, Jinfang, Li, Huiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605293/
https://www.ncbi.nlm.nih.gov/pubmed/34853720
http://dx.doi.org/10.1016/j.omtn.2021.10.026

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