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Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology
Understanding pathways that might impact coronavirus disease 2019 (COVID-19) manifestations and disease outcomes is necessary for better disease management and for therapeutic development. Here, we analyzed alterations in sphingolipid (SL) levels upon infection with severe acute respiratory syndrome...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Life Science Alliance LLC
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605327/ https://www.ncbi.nlm.nih.gov/pubmed/34764206 http://dx.doi.org/10.26508/lsa.202101168 |
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author | Vitner, Einat B Avraham, Roy Politi, Boaz Melamed, Sharon Israely, Tomer |
author_facet | Vitner, Einat B Avraham, Roy Politi, Boaz Melamed, Sharon Israely, Tomer |
author_sort | Vitner, Einat B |
collection | PubMed |
description | Understanding pathways that might impact coronavirus disease 2019 (COVID-19) manifestations and disease outcomes is necessary for better disease management and for therapeutic development. Here, we analyzed alterations in sphingolipid (SL) levels upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infection induced elevation of SL levels in both cells and sera of infected mice. A significant increase in glycosphingolipid levels was induced early post SARS-CoV-2 infection, which was essential for viral replication. This elevation could be reversed by treatment with glucosylceramide synthase inhibitors. Levels of sphinganine, sphingosine, GA1, and GM3 were significantly increased in both cells and the murine model upon SARS-CoV-2 infection. The potential involvement of SLs in COVID-19 pathology is discussed. |
format | Online Article Text |
id | pubmed-8605327 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Life Science Alliance LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-86053272021-12-02 Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology Vitner, Einat B Avraham, Roy Politi, Boaz Melamed, Sharon Israely, Tomer Life Sci Alliance Resources Understanding pathways that might impact coronavirus disease 2019 (COVID-19) manifestations and disease outcomes is necessary for better disease management and for therapeutic development. Here, we analyzed alterations in sphingolipid (SL) levels upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infection induced elevation of SL levels in both cells and sera of infected mice. A significant increase in glycosphingolipid levels was induced early post SARS-CoV-2 infection, which was essential for viral replication. This elevation could be reversed by treatment with glucosylceramide synthase inhibitors. Levels of sphinganine, sphingosine, GA1, and GM3 were significantly increased in both cells and the murine model upon SARS-CoV-2 infection. The potential involvement of SLs in COVID-19 pathology is discussed. Life Science Alliance LLC 2021-11-11 /pmc/articles/PMC8605327/ /pubmed/34764206 http://dx.doi.org/10.26508/lsa.202101168 Text en © 2021 Vitner et al. https://creativecommons.org/licenses/by/4.0/This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Resources Vitner, Einat B Avraham, Roy Politi, Boaz Melamed, Sharon Israely, Tomer Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology |
title | Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology |
title_full | Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology |
title_fullStr | Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology |
title_full_unstemmed | Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology |
title_short | Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology |
title_sort | elevation in sphingolipid upon sars-cov-2 infection: possible implications for covid-19 pathology |
topic | Resources |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605327/ https://www.ncbi.nlm.nih.gov/pubmed/34764206 http://dx.doi.org/10.26508/lsa.202101168 |
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