Cargando…

Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology

Understanding pathways that might impact coronavirus disease 2019 (COVID-19) manifestations and disease outcomes is necessary for better disease management and for therapeutic development. Here, we analyzed alterations in sphingolipid (SL) levels upon infection with severe acute respiratory syndrome...

Descripción completa

Detalles Bibliográficos
Autores principales: Vitner, Einat B, Avraham, Roy, Politi, Boaz, Melamed, Sharon, Israely, Tomer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605327/
https://www.ncbi.nlm.nih.gov/pubmed/34764206
http://dx.doi.org/10.26508/lsa.202101168
_version_ 1784602155089395712
author Vitner, Einat B
Avraham, Roy
Politi, Boaz
Melamed, Sharon
Israely, Tomer
author_facet Vitner, Einat B
Avraham, Roy
Politi, Boaz
Melamed, Sharon
Israely, Tomer
author_sort Vitner, Einat B
collection PubMed
description Understanding pathways that might impact coronavirus disease 2019 (COVID-19) manifestations and disease outcomes is necessary for better disease management and for therapeutic development. Here, we analyzed alterations in sphingolipid (SL) levels upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infection induced elevation of SL levels in both cells and sera of infected mice. A significant increase in glycosphingolipid levels was induced early post SARS-CoV-2 infection, which was essential for viral replication. This elevation could be reversed by treatment with glucosylceramide synthase inhibitors. Levels of sphinganine, sphingosine, GA1, and GM3 were significantly increased in both cells and the murine model upon SARS-CoV-2 infection. The potential involvement of SLs in COVID-19 pathology is discussed.
format Online
Article
Text
id pubmed-8605327
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Life Science Alliance LLC
record_format MEDLINE/PubMed
spelling pubmed-86053272021-12-02 Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology Vitner, Einat B Avraham, Roy Politi, Boaz Melamed, Sharon Israely, Tomer Life Sci Alliance Resources Understanding pathways that might impact coronavirus disease 2019 (COVID-19) manifestations and disease outcomes is necessary for better disease management and for therapeutic development. Here, we analyzed alterations in sphingolipid (SL) levels upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infection induced elevation of SL levels in both cells and sera of infected mice. A significant increase in glycosphingolipid levels was induced early post SARS-CoV-2 infection, which was essential for viral replication. This elevation could be reversed by treatment with glucosylceramide synthase inhibitors. Levels of sphinganine, sphingosine, GA1, and GM3 were significantly increased in both cells and the murine model upon SARS-CoV-2 infection. The potential involvement of SLs in COVID-19 pathology is discussed. Life Science Alliance LLC 2021-11-11 /pmc/articles/PMC8605327/ /pubmed/34764206 http://dx.doi.org/10.26508/lsa.202101168 Text en © 2021 Vitner et al. https://creativecommons.org/licenses/by/4.0/This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
spellingShingle Resources
Vitner, Einat B
Avraham, Roy
Politi, Boaz
Melamed, Sharon
Israely, Tomer
Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology
title Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology
title_full Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology
title_fullStr Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology
title_full_unstemmed Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology
title_short Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology
title_sort elevation in sphingolipid upon sars-cov-2 infection: possible implications for covid-19 pathology
topic Resources
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605327/
https://www.ncbi.nlm.nih.gov/pubmed/34764206
http://dx.doi.org/10.26508/lsa.202101168
work_keys_str_mv AT vitnereinatb elevationinsphingolipiduponsarscov2infectionpossibleimplicationsforcovid19pathology
AT avrahamroy elevationinsphingolipiduponsarscov2infectionpossibleimplicationsforcovid19pathology
AT politiboaz elevationinsphingolipiduponsarscov2infectionpossibleimplicationsforcovid19pathology
AT melamedsharon elevationinsphingolipiduponsarscov2infectionpossibleimplicationsforcovid19pathology
AT israelytomer elevationinsphingolipiduponsarscov2infectionpossibleimplicationsforcovid19pathology